======= DMTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DMTN
  * **<color #00a2e8>Official Name</color>**: dematin actin binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2039|2039]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08495|Q08495]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DMTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DMTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125305|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VHP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein secretion by platelet|
|positive regulation of platelet aggregation|
|calcium-mediated signaling using extracellular calcium source|
|positive regulation of platelet activation|
|negative regulation of protein targeting to membrane|
|positive regulation of homotypic cell-cell adhesion|
|positive regulation of integrin-mediated signaling pathway|
|spectrin-associated cytoskeleton|
|actin filament reorganization|
|platelet dense tubular network membrane|
|cell projection membrane|
|positive regulation of fibroblast migration|
|negative regulation of substrate adhesion-dependent cell spreading|
|regulation of integrin-mediated signaling pathway|
|regulation of platelet aggregation|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of focal adhesion assembly|
|cortical cytoskeleton|
|negative regulation of adherens junction organization|
|calcium-mediated signaling using intracellular calcium source|
|negative regulation of cell junction assembly|
|regulation of homotypic cell-cell adhesion|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|negative regulation of peptidyl-serine phosphorylation|
|positive regulation of coagulation|
|spectrin binding|
|regulation of lamellipodium assembly|
|negative regulation of protein localization to membrane|
|regulation of fibroblast migration|
|regulation of platelet activation|
|erythrocyte development|
|actin filament capping|
|lamellipodium assembly|
|negative regulation of actin filament depolymerization|
|regulation of protein targeting to membrane|
|positive regulation of substrate adhesion-dependent cell spreading|
|negative regulation of cell-matrix adhesion|
|negative regulation of intracellular protein transport|
|lamellipodium organization|
|regulation of lamellipodium organization|
|regulation of peptidyl-threonine phosphorylation|
|regulation of filopodium assembly|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of wound healing|
|cellular response to cAMP|
|protein self-association|
|myeloid cell development|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of intracellular transport|
|negative regulation of protein depolymerization|
|negative regulation of cell-substrate adhesion|
|actin filament bundle assembly|
|positive regulation of response to wounding|
|actin cytoskeleton reorganization|
|actin filament bundle organization|
|negative regulation of protein polymerization|
|regulation of adherens junction organization|
|exocytic process|
|negative regulation of protein complex disassembly|
|endomembrane system|
|regulation of blood coagulation|
|regulation of hemostasis|
|erythrocyte differentiation|
|actin filament|
|regulation of protein targeting|
|regulation of coagulation|
|cellular response to calcium ion|
|regulation of protein depolymerization|
|regulation of cell junction assembly|
|erythrocyte homeostasis|
|negative regulation of cell morphogenesis involved in differentiation|
|response to cAMP|
|myeloid cell homeostasis|
|negative regulation of cellular protein localization|
|regulation of protein complex disassembly|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|platelet degranulation|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|response to organophosphorus|
|regulation of peptidyl-serine phosphorylation|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|calcium-mediated signaling|
|response to calcium ion|
|regulation of cell shape|
|response to purine-containing compound|
|positive regulation of cell morphogenesis involved in differentiation|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|regulation of actin filament polymerization|
|regulation of response to wounding|
|peptide secretion|
|negative regulation of protein transport|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|cellular response to metal ion|
|regulation of plasma membrane bounded cell projection assembly|
|homeostasis of number of cells|
|regulation of cell projection assembly|
|actin filament binding|
|regulation of cell-substrate adhesion|
|actin cytoskeleton|
|cellular response to inorganic substance|
|myeloid cell differentiation|
|regulation of protein polymerization|
|regulation of intracellular protein transport|
|actin filament organization|
|postsynaptic density|
|cytoplasmic vesicle|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of actin filament organization|
|actin binding|
|negative regulation of cell adhesion|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cell development|
|signaling receptor binding|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|response to metal ion|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|negative regulation of transport|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of locomotion|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|establishment of protein localization|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DMTN Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>