======= DNAJC7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC7
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7266|7266]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99615|Q99615]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601964|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 2|
|TPR 1|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chaperone cofactor-dependent protein refolding|
|de novo posttranslational protein folding|
|de novo protein folding|
|chaperone-mediated protein folding|
|heat shock protein binding|
|regulation of cellular response to heat|
|protein folding|
|cytoskeleton|
|regulation of cellular response to stress|
|regulation of response to stress|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.59|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.1|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.87|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.78|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.75|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.79|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.97|
|[[:results:exp539|42°C R08 exp539]]|2.19|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11156
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC7 Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>