======= DNMT3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNMT3B
  * **<color #00a2e8>Official Name</color>**: DNA methyltransferase 3 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1789|1789]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBC3|Q9UBC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNMT3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNMT3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWWP|
|DNA methylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA (cytosine-5-)-methyltransferase activity|
|DNA-methyltransferase activity|
|C-5 methylation of cytosine|
|DNA methylation on cytosine|
|cellular response to hyperoxia|
|negative regulation of histone H3-K9 methylation|
|cellular response to increased oxygen levels|
|positive regulation of histone H3-K4 methylation|
|response to diuretic|
|response to caffeine|
|response to vitamin A|
|negative regulation of histone methylation|
|response to hyperoxia|
|regulation of histone H3-K9 methylation|
|regulation of histone H3-K4 methylation|
|response to increased oxygen levels|
|cellular response to dexamethasone stimulus|
|positive regulation of histone methylation|
|response to dexamethasone|
|negative regulation of histone modification|
|DNA alkylation|
|DNA methylation|
|response to cocaine|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|negative regulation of chromatin organization|
|regulation of histone methylation|
|response to activity|
|DNA methylation or demethylation|
|response to anesthetic|
|negative regulation of gene expression, epigenetic|
|response to vitamin|
|DNA modification|
|positive regulation of histone modification|
|cellular response to ketone|
|response to antineoplastic agent|
|positive regulation of chromatin organization|
|histone deacetylase binding|
|response to alkaloid|
|negative regulation of chromosome organization|
|response to estradiol|
|response to glucocorticoid|
|regulation of histone modification|
|response to ionizing radiation|
|response to purine-containing compound|
|response to corticosteroid|
|positive regulation of chromosome organization|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|response to ketone|
|cellular response to oxygen levels|
|response to nutrient|
|regulation of gene expression, epigenetic|
|transcription corepressor activity|
|macromolecule methylation|
|response to xenobiotic stimulus|
|methylation|
|response to steroid hormone|
|response to hypoxia|
|regulation of chromosome organization|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|response to oxygen levels|
|chromatin binding|
|cellular response to drug|
|response to radiation|
|positive regulation of neurogenesis|
|response to nutrient levels|
|response to toxic substance|
|cellular response to lipid|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|intracellular membrane-bounded organelle|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of neurogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.04|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNMT3B Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>