======= DPEP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPEP1
  * **<color #00a2e8>Official Name</color>**: dipeptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1800|1800]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16444|P16444]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPEP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPEP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M19|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular lactam catabolic process|
|cellular lactam metabolic process|
|cellular amide catabolic process|
|metallodipeptidase activity|
|modified amino acid binding|
|GPI anchor binding|
|homocysteine metabolic process|
|metalloexopeptidase activity|
|dipeptidyl-peptidase activity|
|cellular response to nitric oxide|
|cellular response to reactive nitrogen species|
|response to nitric oxide|
|microvillus membrane|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|leukotriene metabolic process|
|sulfur amino acid metabolic process|
|response to bronchodilator|
|glutathione metabolic process|
|apical part of cell|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to calcium ion|
|negative regulation of cysteine-type endopeptidase activity|
|anchored component of membrane|
|antibiotic metabolic process|
|icosanoid metabolic process|
|cellular response to reactive oxygen species|
|xenobiotic metabolic process|
|response to calcium ion|
|fatty acid derivative metabolic process|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|response to reactive oxygen species|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to inorganic substance|
|cellular response to oxidative stress|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|negative regulation of cell motility|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|cellular amino acid metabolic process|
|apical plasma membrane|
|negative regulation of locomotion|
|negative regulation of proteolysis|
|sulfur compound metabolic process|
|response to metal ion|
|response to oxidative stress|
|cellular response to drug|
|regulation of endopeptidase activity|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|cofactor metabolic process|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|drug metabolic process|
|peptide metabolic process|
|response to inorganic substance|
|cell junction|
|cellular response to nitrogen compound|
|regulation of proteolysis|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|apoptotic process|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|proteolysis|
|regulation of hydrolase activity|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6323
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPEP1 Expression in NALM6 Cells: -0.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>