======= DYNLL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYNLL1
  * **<color #00a2e8>Official Name</color>**: dynein light chain LC8-type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8655|8655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63167|P63167]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYNLL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYNLL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601562|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dynein light|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed|
|regulation of ATP-dependent microtubule motor activity, plus-end-directed|
|positive regulation of microtubule motor activity|
|nitric-oxide synthase regulator activity|
|positive regulation of non-motile cilium assembly|
|regulation of microtubule motor activity|
|intraciliary retrograde transport|
|regulation of non-motile cilium assembly|
|cytoplasmic dynein complex|
|motile cilium assembly|
|positive regulation of cilium assembly|
|dynein complex|
|ATP-dependent microtubule motor activity, plus-end-directed|
|dynein intermediate chain binding|
|dynein light intermediate chain binding|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|COP9 signalosome|
|intraciliary transport involved in cilium assembly|
|substantia nigra development|
|ciliary tip|
|intraciliary transport|
|positive regulation of ATPase activity|
|axon cytoplasm|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|scaffold protein binding|
|ficolin-1-rich granule membrane|
|neural nucleus development|
|microtubule-based protein transport|
|protein transport along microtubule|
|positive regulation of insulin secretion|
|tertiary granule membrane|
|positive regulation of organelle assembly|
|mitotic spindle|
|regulation of cilium assembly|
|regulation of ATPase activity|
|midbrain development|
|kinetochore|
|ciliary basal body-plasma membrane docking|
|positive regulation of peptide hormone secretion|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|positive regulation of plasma membrane bounded cell projection assembly|
|positive regulation of hormone secretion|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|spermatid development|
|transport along microtubule|
|spermatid differentiation|
|macroautophagy|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of insulin secretion|
|membrane docking|
|microtubule-based transport|
|antigen processing and presentation of exogenous antigen|
|protein C-terminus binding|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cilium|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of peptide hormone secretion|
|regulation of cell cycle G2/M phase transition|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|regulation of organelle assembly|
|protein domain specific binding|
|protein-containing complex localization|
|germ cell development|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of hormone secretion|
|mitotic cell cycle phase transition|
|positive regulation of protein secretion|
|microtubule-based movement|
|cell cycle phase transition|
|positive regulation of peptide secretion|
|microtubule|
|cilium assembly|
|enzyme binding|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|Golgi vesicle transport|
|positive regulation of cell projection organization|
|positive regulation of secretion by cell|
|regulation of mitotic cell cycle phase transition|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|neutrophil degranulation|
|protein heterodimerization activity|
|centrosome|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|spermatogenesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|regulation of cellular component biogenesis|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|intracellular protein transport|
|cell cycle process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.04|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.76|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.72|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.7|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.83|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.84|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.86|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.88|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.08|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.22|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.26|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.31|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.66|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.81|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.9|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atmin|ATMIN]]|0.683|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/25|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/15|
|kidney|2/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYNLL1 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>