======= DYRK1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DYRK1A
  * **<color #00a2e8>Official Name</color>**: dual specificity tyrosine phosphorylation regulated kinase 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1859|1859]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13627|Q13627]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DYRK1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DYRK1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600855|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). {ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amyloid-beta formation|
|peptidyl-serine autophosphorylation|
|amyloid precursor protein catabolic process|
|negative regulation of microtubule polymerization|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|amyloid precursor protein metabolic process|
|negative regulation of mRNA splicing, via spliceosome|
|amyloid-beta metabolic process|
|tau-protein kinase activity|
|positive regulation of protein deacetylation|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|protein serine/threonine/tyrosine kinase activity|
|negative regulation of signal transduction by p53 class mediator|
|peptidyl-tyrosine autophosphorylation|
|positive regulation of RNA splicing|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of protein deacetylation|
|tau protein binding|
|non-membrane spanning protein tyrosine kinase activity|
|regulation of microtubule polymerization|
|protein self-association|
|regulation of alternative mRNA splicing, via spliceosome|
|negative regulation of protein polymerization|
|cytoskeletal protein binding|
|negative regulation of mRNA metabolic process|
|regulation of microtubule polymerization or depolymerization|
|negative regulation of response to DNA damage stimulus|
|peptidyl-threonine phosphorylation|
|protein tyrosine kinase activity|
|peptidyl-threonine modification|
|regulation of mRNA splicing, via spliceosome|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|regulation of RNA splicing|
|regulation of mRNA processing|
|negative regulation of cytoskeleton organization|
|circadian rhythm|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|ribonucleoprotein complex|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|regulation of microtubule cytoskeleton organization|
|protein autophosphorylation|
|peptidyl-serine modification|
|regulation of response to DNA damage stimulus|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|protein kinase activity|
|rhythmic process|
|axon|
|regulation of mRNA metabolic process|
|regulation of supramolecular fiber organization|
|protein serine/threonine kinase activity|
|cytoskeleton|
|negative regulation of organelle organization|
|nuclear speck|
|dendrite|
|regulation of protein complex assembly|
|negative regulation of intracellular signal transduction|
|peptide metabolic process|
|regulation of cytoskeleton organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|identical protein binding|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|ATP binding|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.41|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.27|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.2|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.04|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.01|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.92|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.91|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.88|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.86|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.85|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.82|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.81|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.74|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.72|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.7|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.21|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.86|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DYRK1A Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>