======= ECSIT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ECSIT
  * **<color #00a2e8>Official Name</color>**: ECSIT signaling integrator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51295|51295]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ95|Q9BQ95]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ECSIT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ECSIT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608388|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ECSIT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity, acting on NAD(P)H|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|regulation of oxidoreductase activity|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|innate immune response|
|cellular protein-containing complex assembly|
|defense response to other organism|
|oxidation-reduction process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.05|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.94|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.71|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.86|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.05|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.13|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.18|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.23|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.44|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.47|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.668|
|[[:human genes:n:ndufa3|NDUFA3]]|0.642|
|[[:human genes:n:ndufb6|NDUFB6]]|0.632|
|[[:human genes:n:ndufs2|NDUFS2]]|0.625|
|[[:human genes:n:ndufb5|NDUFB5]]|0.622|
|[[:human genes:n:ndufa2|NDUFA2]]|0.619|
|[[:human genes:g:grsf1|GRSF1]]|0.612|
|[[:human genes:n:ndufa1|NDUFA1]]|0.61|
|[[:human genes:n:ndufa11|NDUFA11]]|0.599|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.591|
|[[:human genes:m:mto1|MTO1]]|0.586|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.581|
|[[:human genes:n:ndufb9|NDUFB9]]|0.568|
|[[:human genes:c:c17orf89|C17orf89]]|0.566|
|[[:human genes:a:acad9|ACAD9]]|0.564|
|[[:human genes:n:ndufa10|NDUFA10]]|0.562|
|[[:human genes:n:nubpl|NUBPL]]|0.561|
|[[:human genes:n:ndufs8|NDUFS8]]|0.56|
|[[:human genes:n:ndufa8|NDUFA8]]|0.554|
|[[:human genes:n:ndufc2|NDUFC2]]|0.552|
|[[:human genes:n:ndufa6|NDUFA6]]|0.552|
|[[:human genes:n:ndufv2|NDUFV2]]|0.551|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.548|
|[[:human genes:n:ndufb2|NDUFB2]]|0.547|
|[[:human genes:n:ndufs7|NDUFS7]]|0.546|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.544|
|[[:human genes:g:gfm1|GFM1]]|0.531|
|[[:human genes:m:mipep|MIPEP]]|0.53|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.528|
|[[:human genes:m:mcat|MCAT]]|0.526|
|[[:human genes:n:ndufb7|NDUFB7]]|0.525|
|[[:human genes:c:c12orf65|C12orf65]]|0.525|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.523|
|[[:human genes:a:atp5sl|ATP5SL]]|0.522|
|[[:human genes:m:mrps16|MRPS16]]|0.521|
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:n:ndufs5|NDUFS5]]|0.517|
|[[:human genes:n:ndufb10|NDUFB10]]|0.509|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.508|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.505|
|[[:human genes:n:ndufv1|NDUFV1]]|0.504|
|[[:human genes:l:lars2|LARS2]]|0.503|
|[[:human genes:m:malsu1|MALSU1]]|0.503|
|[[:human genes:n:ndufs3|NDUFS3]]|0.502|
|[[:human genes:f:foxred1|FOXRED1]]|0.5|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.498|
|[[:human genes:t:tars2|TARS2]]|0.498|
|[[:human genes:r:rpusd3|RPUSD3]]|0.498|
|[[:human genes:m:mrps21|MRPS21]]|0.495|
|[[:human genes:i:iba57|IBA57]]|0.493|
|[[:human genes:f:ftsj2|FTSJ2]]|0.493|
|[[:human genes:m:mrps5|MRPS5]]|0.492|
|[[:human genes:f:fastkd2|FASTKD2]]|0.491|
|[[:human genes:t:tmem261|TMEM261]]|0.491|
|[[:human genes:m:mtg2|MTG2]]|0.489|
|[[:human genes:r:rpusd4|RPUSD4]]|0.487|
|[[:human genes:p:polg2|POLG2]]|0.485|
|[[:human genes:e:ears2|EARS2]]|0.484|
|[[:human genes:n:ndufc1|NDUFC1]]|0.484|
|[[:human genes:c:chchd1|CHCHD1]]|0.483|
|[[:human genes:q:qrsl1|QRSL1]]|0.483|
|[[:human genes:c:c10orf2|C10orf2]]|0.483|
|[[:human genes:m:mrpl45|MRPL45]]|0.482|
|[[:human genes:y:yars2|YARS2]]|0.481|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.479|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.478|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.476|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.475|
|[[:human genes:g:gatc|GATC]]|0.474|
|[[:human genes:p:pet117|PET117]]|0.474|
|[[:human genes:s:selrc1|SELRC1]]|0.473|
|[[:human genes:a:aars2|AARS2]]|0.473|
|[[:human genes:n:ndufb4|NDUFB4]]|0.466|
|[[:human genes:n:nfu1|NFU1]]|0.461|
|[[:human genes:v:vars2|VARS2]]|0.46|
|[[:human genes:m:mrpl21|MRPL21]]|0.458|
|[[:human genes:m:mars2|MARS2]]|0.457|
|[[:human genes:w:wbscr16|WBSCR16]]|0.457|
|[[:human genes:c:coa6|COA6]]|0.456|
|[[:human genes:n:ndufs1|NDUFS1]]|0.456|
|[[:human genes:c:coq2|COQ2]]|0.456|
|[[:human genes:c:cox16|COX16]]|0.455|
|[[:human genes:g:glrx5|GLRX5]]|0.454|
|[[:human genes:m:mrps26|MRPS26]]|0.452|
|[[:human genes:m:mrps6|MRPS6]]|0.451|
|[[:human genes:p:pet112|PET112]]|0.45|
|[[:human genes:s:sco2|SCO2]]|0.45|
|[[:human genes:r:rbfa|RBFA]]|0.45|
|[[:human genes:p:polg|POLG]]|0.449|
|[[:human genes:m:mrp63|MRP63]]|0.447|
|[[:human genes:n:nars2|NARS2]]|0.445|
|[[:human genes:m:mrps34|MRPS34]]|0.445|
|[[:human genes:m:mrps33|MRPS33]]|0.444|
|[[:human genes:m:mrps2|MRPS2]]|0.444|
|[[:human genes:n:ndufa13|NDUFA13]]|0.443|
|[[:human genes:t:trub2|TRUB2]]|0.442|
|[[:human genes:m:mrpl53|MRPL53]]|0.441|
|[[:human genes:m:mrpl47|MRPL47]]|0.44|
|[[:human genes:t:tefm|TEFM]]|0.44|
|[[:human genes:m:mrpl55|MRPL55]]|0.439|
|[[:human genes:s:sars2|SARS2]]|0.438|
|[[:human genes:c:cars2|CARS2]]|0.436|
|[[:human genes:m:mrps25|MRPS25]]|0.435|
|[[:human genes:g:got2|GOT2]]|0.435|
|[[:human genes:t:tomm20|TOMM20]]|0.434|
|[[:human genes:m:mrpl13|MRPL13]]|0.433|
|[[:human genes:e:eral1|ERAL1]]|0.43|
|[[:human genes:i:isca2|ISCA2]]|0.43|
|[[:human genes:t:tfb1m|TFB1M]]|0.43|
|[[:human genes:a:aifm1|AIFM1]]|0.429|
|[[:human genes:m:mettl17|METTL17]]|0.427|
|[[:human genes:i:ict1|ICT1]]|0.426|
|[[:human genes:m:mrpl12|MRPL12]]|0.425|
|[[:human genes:m:mrpl15|MRPL15]]|0.424|
|[[:human genes:d:dap3|DAP3]]|0.423|
|[[:human genes:f:fars2|FARS2]]|0.423|
|[[:human genes:m:mrpl23|MRPL23]]|0.42|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.42|
|[[:human genes:b:bcs1l|BCS1L]]|0.419|
|[[:human genes:m:mrps12|MRPS12]]|0.419|
|[[:human genes:w:wars2|WARS2]]|0.417|
|[[:human genes:p:ptcd3|PTCD3]]|0.417|
|[[:human genes:d:ddx28|DDX28]]|0.417|
|[[:human genes:n:ndufb3|NDUFB3]]|0.417|
|[[:human genes:d:dars2|DARS2]]|0.416|
|[[:human genes:m:mtg1|MTG1]]|0.416|
|[[:human genes:f:fastkd5|FASTKD5]]|0.413|
|[[:human genes:n:nsun4|NSUN4]]|0.413|
|[[:human genes:s:ssbp1|SSBP1]]|0.412|
|[[:human genes:p:pars2|PARS2]]|0.411|
|[[:human genes:m:mtif2|MTIF2]]|0.411|
|[[:human genes:c:cox11|COX11]]|0.409|
|[[:human genes:c:coq4|COQ4]]|0.409|
|[[:human genes:m:mrpl1|MRPL1]]|0.408|
|[[:human genes:c:coa3|COA3]]|0.407|
|[[:human genes:m:mrps35|MRPS35]]|0.407|
|[[:human genes:p:pdss1|PDSS1]]|0.404|
|[[:human genes:s:sfxn4|SFXN4]]|0.402|
|[[:human genes:t:tmem242|TMEM242]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ECSIT Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>