======= EEF1A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF1A2
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation elongation factor 1 alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1917|1917]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05639|Q05639]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF1A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF1A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602959|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU D2|
|GTP EFTU D3|
|GTP EFTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation elongation factor 1 complex|
|cytoplasmic side of lysosomal membrane|
|regulation of chaperone-mediated autophagy|
|translation elongation factor activity|
|translation factor activity, RNA binding|
|positive regulation of lipid kinase activity|
|response to electrical stimulus|
|regulation of lipid kinase activity|
|translational elongation|
|positive regulation of lipid metabolic process|
|synapse|
|GTPase activity|
|regulation of autophagy|
|neuronal cell body|
|translation|
|regulation of protein catabolic process|
|GTP binding|
|regulation of lipid metabolic process|
|peptide biosynthetic process|
|protein kinase binding|
|amide biosynthetic process|
|peptide metabolic process|
|response to inorganic substance|
|positive regulation of kinase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|positive regulation of cell death|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|regulation of transferase activity|
|regulation of catabolic process|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF1A2 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>