======= EHMT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EHMT2
  * **<color #00a2e8>Official Name</color>**: euchromatic histone lysine methyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10919|10919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KQ7|Q96KQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EHMT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EHMT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
|SET|
|Pre-SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone methyltransferase activity (H3-K27 specific)|
|histone methyltransferase activity (H3-K9 specific)|
|histone H3-K27 methylation|
|peptidyl-lysine dimethylation|
|C2H2 zinc finger domain binding|
|histone H3-K9 methylation|
|histone-lysine N-methyltransferase activity|
|histone H3-K9 modification|
|protein-lysine N-methyltransferase activity|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|DNA methylation|
|DNA alkylation|
|promoter-specific chromatin binding|
|DNA methylation or demethylation|
|p53 binding|
|histone lysine methylation|
|DNA modification|
|peptidyl-lysine methylation|
|histone methylation|
|regulation of DNA replication|
|protein methylation|
|protein alkylation|
|cellular response to starvation|
|regulation of signal transduction by p53 class mediator|
|response to starvation|
|cellular response to nutrient levels|
|nuclear chromatin|
|macromolecule methylation|
|cellular response to extracellular stimulus|
|methylation|
|peptidyl-lysine modification|
|negative regulation of cell cycle process|
|cellular response to external stimulus|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|chromatin organization|
|DNA metabolic process|
|regulation of cell cycle process|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.88|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.501|
|[[:human genes:i:ing5|ING5]]|0.463|
|[[:human genes:s:setdb1|SETDB1]]|0.458|
|[[:human genes:m:med13l|MED13L]]|0.442|
|[[:human genes:t:taf6l|TAF6L]]|0.44|
|[[:human genes:t:taf5l|TAF5L]]|0.425|
|[[:human genes:z:znf592|ZNF592]]|0.42|
|[[:human genes:h:hdac8|HDAC8]]|0.415|
|[[:human genes:a:aff1|AFF1]]|0.414|
|[[:human genes:t:tmem161b|TMEM161B]]|0.414|
|[[:human genes:m:max|MAX]]|0.411|
|[[:human genes:e:ehmt1|EHMT1]]|0.409|
|[[:human genes:a:atp1a1|ATP1A1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1430
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EHMT2 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>