======= EIF2AK4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2AK4
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2 alpha kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440275|440275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2K8|Q9P2K8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2AK4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2AK4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HGTP anticodon2|
|Pkinase Tyr|
|Pkinase|
|RWD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|induction by virus of host autophagy|
|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|
|regulation of eIF2 alpha phosphorylation by amino acid starvation|
|regulation of translational initiation in response to starvation|
|modulation by virus of host autophagy|
|positive regulation of translational initiation in response to starvation|
|regulation of autophagic cell death|
|regulation of translation initiation in response to endoplasmic reticulum stress|
|eukaryotic translation initiation factor 2alpha kinase activity|
|regulation of translational initiation by eIF2 alpha phosphorylation|
|positive regulation of translational initiation in response to stress|
|negative regulation of translational initiation in response to stress|
|positive regulation by symbiont of host autophagy|
|regulation of translation in response to endoplasmic reticulum stress|
|modulation by symbiont of host autophagy|
|positive regulation of translation in response to stress|
|negative regulation of translation in response to stress|
|negative regulation by host of viral genome replication|
|negative regulation of CREB transcription factor activity|
|cytosolic ribosome|
|modulation by symbiont of host programmed cell death|
|cellular response to cold|
|cellular response to leucine starvation|
|regulation of translational initiation in response to stress|
|negative regulation by host of viral process|
|viral translation|
|modulation by host of viral genome replication|
|regulation of translation in response to stress|
|modulation by virus of host cellular process|
|negative regulation of translational initiation|
|positive regulation of long-term synaptic potentiation|
|modulation by symbiont of host cellular process|
|positive regulation of defense response to virus by host|
|regulation of feeding behavior|
|modulation by host of viral process|
|positive regulation of translational initiation|
|modulation by virus of host morphology or physiology|
|long-term memory|
|regulation of defense response to virus by host|
|modification by symbiont of host morphology or physiology|
|cellular response to amino acid starvation|
|polysome|
|regulation of long-term synaptic potentiation|
|response to amino acid starvation|
|response to cold|
|negative regulation of viral genome replication|
|neuron projection extension|
|tRNA binding|
|T cell activation involved in immune response|
|modification by host of symbiont morphology or physiology|
|regulation of behavior|
|regulation of defense response to virus|
|interaction with symbiont|
|regulation of translational initiation|
|negative regulation of viral life cycle|
|cellular response to UV|
|developmental cell growth|
|cell growth|
|regulation of viral genome replication|
|negative regulation of viral process|
|positive regulation of adaptive immune response|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|lymphocyte activation involved in immune response|
|cellular response to light stimulus|
|developmental growth involved in morphogenesis|
|memory|
|positive regulation of autophagy|
|positive regulation of translation|
|viral gene expression|
|negative regulation of translation|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|regulation of viral life cycle|
|cell cycle arrest|
|learning|
|negative regulation of cellular amide metabolic process|
|positive regulation of cellular amide metabolic process|
|positive regulation of synaptic transmission|
|cellular response to starvation|
|modification of morphology or physiology of other organism|
|interaction with host|
|negative regulation of DNA-binding transcription factor activity|
|regulation of adaptive immune response|
|cellular response to radiation|
|response to temperature stimulus|
|regulation of synaptic plasticity|
|defense response to virus|
|protein autophosphorylation|
|response to starvation|
|cell cycle checkpoint|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of neuron differentiation|
|cellular response to nutrient levels|
|T cell activation|
|protein kinase activity|
|response to endoplasmic reticulum stress|
|learning or memory|
|cellular response to extracellular stimulus|
|response to virus|
|negative regulation of neurogenesis|
|cognition|
|response to light stimulus|
|negative regulation of nervous system development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of autophagy|
|negative regulation of cell development|
|cellular response to external stimulus|
|regulation of translation|
|protein serine/threonine kinase activity|
|positive regulation of cellular catabolic process|
|lymphocyte activation|
|developmental growth|
|growth|
|regulation of cellular amide metabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of immune effector process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|cell part morphogenesis|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|behavior|
|negative regulation of cell cycle|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of neuron differentiation|
|neuron projection development|
|viral process|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of defense response|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|protein phosphorylation|
|regulation of catabolic process|
|cell cycle process|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.26|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.84|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.43|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.53|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|6.27|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|6.69|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|8.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gcn1l1|GCN1L1]]|0.593|
|[[:human genes:s:serbp1|SERBP1]]|0.531|
|[[:human genes:c:cebpg|CEBPG]]|0.45|
|[[:human genes:r:rps10|RPS10]]|0.446|
|[[:human genes:e:eif4b|EIF4B]]|0.423|
|[[:human genes:r:rps12|RPS12]]|0.411|
|[[:human genes:r:rplp1|RPLP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 25/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|2/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|4/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2AK4 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>