======= EIF3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3A
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8661|8661]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14152|Q14152]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602039|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP- Rule:MF_03000, ECO:0000269|PubMed:11169732, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 3 complex, eIF3e|
|multi-eIF complex|
|translation reinitiation|
|viral translational termination-reinitiation|
|eukaryotic translation initiation factor 3 complex, eIF3m|
|IRES-dependent viral translational initiation|
|viral translation|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|receptor tyrosine kinase binding|
|negative regulation of ERK1 and ERK2 cascade|
|cytoplasmic translation|
|viral gene expression|
|translational initiation|
|mRNA binding|
|negative regulation of MAPK cascade|
|structural molecule activity|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|postsynaptic density|
|regulation of ERK1 and ERK2 cascade|
|microtubule|
|translation|
|negative regulation of protein phosphorylation|
|peptide biosynthetic process|
|negative regulation of phosphorylation|
|ribonucleoprotein complex biogenesis|
|negative regulation of intracellular signal transduction|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|viral process|
|regulation of MAPK cascade|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.91|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.7|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.7|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.71|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.72|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.74|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.75|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.76|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.77|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.79|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.8|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.82|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.83|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.83|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.84|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.85|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.87|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.87|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.91|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.91|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.95|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.97|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.98|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.99|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.03|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.04|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.04|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.08|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.08|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.11|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.16|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.17|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.17|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.18|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.22|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.29|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.3|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.32|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.37|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.37|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.37|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.41|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.45|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.47|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.47|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.52|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.6|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.62|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.67|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.69|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.74|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.8|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3.23|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif3g|EIF3G]]|0.581|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.484|
|[[:human genes:r:rps12|RPS12]]|0.433|
|[[:human genes:t:tfip11|TFIP11]]|0.422|
|[[:human genes:p:psmb4|PSMB4]]|0.421|
|[[:human genes:e:eif3cl|EIF3CL]]|0.419|
|[[:human genes:e:eif4b|EIF4B]]|0.417|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.411|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.401|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.4|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1483
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3A Expression in NALM6 Cells: 9.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>