======= EIF3G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3G
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8666|8666]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75821|O75821]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603913|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). This subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF3g|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral translational termination-reinitiation|
|viral translation|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|cytoplasmic translation|
|viral gene expression|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|translation|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|perinuclear region of cytoplasm|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.71|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.72|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.72|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.75|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.76|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.77|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.78|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.79|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.82|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.83|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.85|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.88|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.88|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.89|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.9|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.94|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.96|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.96|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.97|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.99|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.05|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.06|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.13|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.18|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.27|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.31|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.32|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.35|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.4|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.47|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.49|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.8|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.84|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.96|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.97|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.05|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.08|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.19|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|3.19|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.76|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif3a|EIF3A]]|0.581|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.555|
|[[:human genes:t:tfip11|TFIP11]]|0.511|
|[[:human genes:r:rps12|RPS12]]|0.485|
|[[:human genes:s:sf3a2|SF3A2]]|0.479|
|[[:human genes:u:utp3|UTP3]]|0.445|
|[[:human genes:r:rps2|RPS2]]|0.444|
|[[:human genes:d:ddx3x|DDX3X]]|0.434|
|[[:human genes:e:eif4a1|EIF4A1]]|0.433|
|[[:human genes:r:rnf113a|RNF113A]]|0.431|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
|[[:human genes:i:ints5|INTS5]]|0.425|
|[[:human genes:r:rps10|RPS10]]|0.422|
|[[:human genes:e:eif4b|EIF4B]]|0.419|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:t:tceb3c|TCEB3C]]|0.418|
|[[:human genes:c:cln6|CLN6]]|0.418|
|[[:human genes:c:copg1|COPG1]]|0.418|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.417|
|[[:human genes:p:psmb4|PSMB4]]|0.417|
|[[:human genes:r:rpl35|RPL35]]|0.415|
|[[:human genes:o:orc6|ORC6]]|0.414|
|[[:human genes:n:nsf|NSF]]|0.414|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.413|
|[[:human genes:p:plekha4|PLEKHA4]]|0.412|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.41|
|[[:human genes:z:znf148|ZNF148]]|0.41|
|[[:human genes:i:ints6|INTS6]]|0.408|
|[[:human genes:v:vps28|VPS28]]|0.406|
|[[:human genes:r:rps19|RPS19]]|0.403|
|[[:human genes:c:cdc73|CDC73]]|0.402|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1111
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3G Expression in NALM6 Cells: 7.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>