======= EIF4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4B
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1975|1975]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23588|P23588]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA strand-exchange activity|
|eukaryotic translation initiation factor 4F complex assembly|
|RNA strand annealing activity|
|formation of translation preinitiation complex|
|eukaryotic translation initiation factor 4F complex|
|ribosomal small subunit binding|
|cytoplasmic translational initiation|
|polysome|
|translation initiation factor activity|
|cytoplasmic translation|
|regulation of translational initiation|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.68|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.74|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.72|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.74|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.77|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.8|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.8|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.8|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.81|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.83|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.87|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.94|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.96|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.99|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.05|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.06|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.06|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.07|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.08|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.11|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.23|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.3|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.35|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|3.03|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.05|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.1|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddx3x|DDX3X]]|0.494|
|[[:human genes:z:znf148|ZNF148]]|0.456|
|[[:human genes:c:cdk8|CDK8]]|0.455|
|[[:human genes:e:eif4h|EIF4H]]|0.428|
|[[:human genes:t:tsc2|TSC2]]|0.425|
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.423|
|[[:human genes:m:msi2|MSI2]]|0.423|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.423|
|[[:human genes:e:eif3g|EIF3G]]|0.419|
|[[:human genes:e:eif3a|EIF3A]]|0.417|
|[[:human genes:r:rps12|RPS12]]|0.408|
|[[:human genes:a:arid4b|ARID4B]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 46/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|5/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4B Expression in NALM6 Cells: 9.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>