======= EIF4G1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4G1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4 gamma 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1981|1981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04637|Q04637]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4G1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4G1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600495|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF4G|
|W2|
|MA3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of eukaryotic translation initiation factor 4F complex assembly|
|positive regulation of eukaryotic translation initiation factor 4F complex assembly|
|regulation of mRNA cap binding|
|positive regulation of mRNA cap binding|
|positive regulation of miRNA mediated inhibition of translation|
|regulation of polysome binding|
|regulation of miRNA mediated inhibition of translation|
|cap-dependent translational initiation|
|positive regulation of mRNA binding|
|positive regulation of RNA binding|
|regulation of mRNA binding|
|eukaryotic initiation factor 4E binding|
|regulation of RNA binding|
|eukaryotic translation initiation factor 4F complex|
|negative regulation of peptidyl-threonine phosphorylation|
|translation initiation factor binding|
|positive regulation of gene silencing by miRNA|
|translation factor activity, RNA binding|
|positive regulation of posttranscriptional gene silencing|
|regulation of presynapse assembly|
|cytoplasmic translational initiation|
|regulation of presynapse organization|
|behavioral fear response|
|behavioral defense response|
|fear response|
|energy homeostasis|
|positive regulation of G1/S transition of mitotic cell cycle|
|polysome|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of cell cycle G1/S phase transition|
|molecular adaptor activity|
|translation initiation factor activity|
|multicellular organismal response to stress|
|cytoplasmic translation|
|positive regulation of mitotic cell cycle phase transition|
|regulation of translational initiation|
|negative regulation of autophagy|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|positive regulation of cell cycle phase transition|
|regulation of synapse assembly|
|positive regulation of peptidyl-serine phosphorylation|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|regulation of gene silencing|
|regulation of peptidyl-serine phosphorylation|
|translational initiation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|mRNA binding|
|positive regulation of cell growth|
|regulation of cell cycle G1/S phase transition|
|positive regulation of binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|negative regulation of neuron death|
|mRNA catabolic process|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cellular response to nutrient levels|
|RNA catabolic process|
|positive regulation of protein complex assembly|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|positive regulation of cell cycle process|
|negative regulation of catabolic process|
|regulation of neuron death|
|multicellular organismal homeostasis|
|regulation of mRNA metabolic process|
|regulation of autophagy|
|cellular response to external stimulus|
|regulation of translation|
|positive regulation of neuron differentiation|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|regulation of binding|
|translation|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|peptide biosynthetic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|mitochondrion organization|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|positive regulation of neurogenesis|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|negative regulation of protein modification process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|regulation of growth|
|mRNA metabolic process|
|positive regulation of cell death|
|viral process|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|symbiotic process|
|cellular amide metabolic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|regulation of catabolic process|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|identical protein binding|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|defense response|
|positive regulation of developmental process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.1|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.9|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.8|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.74|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.74|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.7|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.72|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.8|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.81|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.84|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.85|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.86|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.86|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.94|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.07|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.15|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.19|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.27|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.29|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.3|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.32|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.48|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.5|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.58|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.69|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.78|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.88|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.03|
|[[:results:exp210|LB-100 2μM R05 exp210]]|3.06|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.38|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.43|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.52|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.67|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|4.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr24|WDR24]]|0.477|
|[[:human genes:m:mtor|MTOR]]|0.451|
|[[:human genes:e:eif4e|EIF4E]]|0.448|
|[[:human genes:e:eif3m|EIF3M]]|0.444|
|[[:human genes:z:zzz3|ZZZ3]]|0.442|
|[[:human genes:w:wdr59|WDR59]]|0.44|
|[[:human genes:r:rptor|RPTOR]]|0.438|
|[[:human genes:l:lsm12|LSM12]]|0.428|
|[[:human genes:f:fnip1|FNIP1]]|0.424|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.415|
|[[:human genes:m:mios|MIOS]]|0.413|
|[[:human genes:i:irf2|IRF2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 114/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|9/26|
|breast|6/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|4/20|
|lung|10/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|2/2|
|upper aerodigestive|1/22|
|urinary tract|7/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1449
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4G1 Expression in NALM6 Cells: 9.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>