======= EN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EN1
  * **<color #00a2e8>Official Name</color>**: engrailed homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2019|2019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05925|Q05925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Engrail 1 C sig|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RSC-type complex|
|motor learning|
|midbrain-hindbrain boundary development|
|drinking behavior|
|rostrocaudal neural tube patterning|
|embryonic brain development|
|dopaminergic neuron differentiation|
|proximal/distal pattern formation|
|embryonic forelimb morphogenesis|
|neural tube patterning|
|forelimb morphogenesis|
|intraspecies interaction between organisms|
|social behavior|
|multi-organism behavior|
|adult locomotory behavior|
|dorsal/ventral pattern formation|
|multicellular organism growth|
|feeding behavior|
|midbrain development|
|pigmentation|
|cerebellum development|
|metencephalon development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|negative regulation of neuron apoptotic process|
|adult behavior|
|learning|
|limb morphogenesis|
|appendage morphogenesis|
|hindbrain development|
|neural tube development|
|appendage development|
|limb development|
|locomotory behavior|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|anterior/posterior pattern specification|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|learning or memory|
|cognition|
|regulation of neuron death|
|regionalization|
|developmental growth|
|growth|
|sequence-specific DNA binding|
|embryonic organ development|
|pattern specification process|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|embryonic morphogenesis|
|behavior|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|brain development|
|head development|
|neuron development|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|neuron differentiation|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.31|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14842
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EN1 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>