======= EPHA7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHA7
  * **<color #00a2e8>Official Name</color>**: EPH receptor A7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2045|2045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15375|Q15375]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHA7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHA7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|GCC2 GCC3|
|fn3|
|Pkinase Tyr|
|Ephrin lbd|
|SAM 2|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branching morphogenesis of a nerve|
|GPI-linked ephrin receptor activity|
|negative regulation of synapse assembly|
|negative regulation of collateral sprouting|
|axon guidance receptor activity|
|nephric duct morphogenesis|
|nephric duct development|
|transmembrane-ephrin receptor activity|
|retinal ganglion cell axon guidance|
|regulation of collateral sprouting|
|negative regulation of synapse organization|
|chemorepellent activity|
|ephrin receptor binding|
|hippocampal mossy fiber to CA3 synapse|
|negative chemotaxis|
|regulation of protein autophosphorylation|
|integral component of postsynaptic density membrane|
|positive regulation of neuron apoptotic process|
|transmembrane receptor protein tyrosine kinase activity|
|negative regulation of axonogenesis|
|neuromuscular junction|
|Schaffer collateral - CA1 synapse|
|ephrin receptor signaling pathway|
|protein tyrosine kinase activity|
|positive regulation of neuron death|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|regulation of synapse assembly|
|regulation of extent of cell growth|
|kidney epithelium development|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|negative regulation of neuron projection development|
|morphogenesis of a branching structure|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|receptor complex|
|regulation of neuron apoptotic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|regulation of peptidyl-tyrosine phosphorylation|
|axon guidance|
|neuron projection guidance|
|kidney development|
|renal system development|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|regulation of neuron death|
|negative regulation of nervous system development|
|urogenital system development|
|neuron projection|
|regulation of developmental growth|
|negative regulation of cell development|
|glutamatergic synapse|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|regulation of cell-cell adhesion|
|axon development|
|regulation of endopeptidase activity|
|regulation of cell growth|
|dendrite|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|regulation of peptidase activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|brain development|
|regulation of MAPK cascade|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|peptidyl-amino acid modification|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHA7 Expression in NALM6 Cells: -1.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>