======= EPS8L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPS8L2
  * **<color #00a2e8>Official Name</color>**: EPS8 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64787|64787]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6S3|Q9H6S3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPS8L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPS8L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614988|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|PID|
|PTB|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stereocilium bundle|
|positive regulation of ruffle assembly|
|stereocilium tip|
|Rac guanyl-nucleotide exchange factor activity|
|regulation of ruffle assembly|
|Rho guanyl-nucleotide exchange factor activity|
|Rho protein signal transduction|
|ruffle membrane|
|positive regulation of plasma membrane bounded cell projection assembly|
|vesicle|
|regulation of Rho protein signal transduction|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|actin binding|
|cadherin binding|
|small GTPase mediated signal transduction|
|regulation of small GTPase mediated signal transduction|
|positive regulation of cell projection organization|
|positive regulation of cellular component biogenesis|
|protein-containing complex|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular component biogenesis|
|sensory perception|
|positive regulation of cellular component organization|
|nervous system process|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.31|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.96|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16055
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPS8L2 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>