======= ERAL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERAL1
  * **<color #00a2e8>Official Name</color>**: Era like 12S mitochondrial rRNA chaperone 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26284|26284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75616|O75616]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERAL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERAL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. {ECO:0000269|PubMed:20430825, ECO:0000269|PubMed:20604745, ECO:0000269|PubMed:28449065}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FeoB N|
|Miro|
|AIG1|
|MMR HSR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit binding|
|ribosomal small subunit assembly|
|rRNA binding|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|ribonucleoprotein complex assembly|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|mitochondrial matrix|
|translation|
|GTP binding|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.72|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.76|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.91|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.97|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.06|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.09|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsun4|NSUN4]]|0.591|
|[[:human genes:p:pet112|PET112]]|0.57|
|[[:human genes:f:ftsj2|FTSJ2]]|0.563|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.557|
|[[:human genes:p:pet117|PET117]]|0.556|
|[[:human genes:a:aars2|AARS2]]|0.556|
|[[:human genes:f:fastkd2|FASTKD2]]|0.541|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.537|
|[[:human genes:n:ndufb10|NDUFB10]]|0.536|
|[[:human genes:m:mrpl45|MRPL45]]|0.535|
|[[:human genes:m:mrps22|MRPS22]]|0.534|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.533|
|[[:human genes:r:rpusd3|RPUSD3]]|0.531|
|[[:human genes:a:acad9|ACAD9]]|0.531|
|[[:human genes:l:lars2|LARS2]]|0.527|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.52|
|[[:human genes:p:prepl|PREPL]]|0.519|
|[[:human genes:n:ndufa1|NDUFA1]]|0.516|
|[[:human genes:d:ddx28|DDX28]]|0.516|
|[[:human genes:n:nars2|NARS2]]|0.516|
|[[:human genes:p:ptcd3|PTCD3]]|0.51|
|[[:human genes:c:cars2|CARS2]]|0.509|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.509|
|[[:human genes:p:pde12|PDE12]]|0.496|
|[[:human genes:q:qrsl1|QRSL1]]|0.496|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.494|
|[[:human genes:m:mrpl3|MRPL3]]|0.491|
|[[:human genes:m:mrpl49|MRPL49]]|0.488|
|[[:human genes:m:mrps16|MRPS16]]|0.487|
|[[:human genes:m:malsu1|MALSU1]]|0.487|
|[[:human genes:m:mrpl22|MRPL22]]|0.482|
|[[:human genes:t:tsfm|TSFM]]|0.482|
|[[:human genes:m:mtif2|MTIF2]]|0.481|
|[[:human genes:g:grsf1|GRSF1]]|0.479|
|[[:human genes:m:mto1|MTO1]]|0.479|
|[[:human genes:c:chchd1|CHCHD1]]|0.478|
|[[:human genes:d:dap3|DAP3]]|0.477|
|[[:human genes:m:mcat|MCAT]]|0.474|
|[[:human genes:n:ndufs2|NDUFS2]]|0.474|
|[[:human genes:n:ndufb11|NDUFB11]]|0.47|
|[[:human genes:m:mrpl28|MRPL28]]|0.468|
|[[:human genes:r:rmnd1|RMND1]]|0.468|
|[[:human genes:e:ears2|EARS2]]|0.468|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.467|
|[[:human genes:m:mrpl17|MRPL17]]|0.467|
|[[:human genes:c:coq2|COQ2]]|0.467|
|[[:human genes:v:vars2|VARS2]]|0.467|
|[[:human genes:m:mettl17|METTL17]]|0.466|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.465|
|[[:human genes:g:gfm2|GFM2]]|0.465|
|[[:human genes:c:coa3|COA3]]|0.464|
|[[:human genes:p:pars2|PARS2]]|0.464|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.461|
|[[:human genes:m:mars2|MARS2]]|0.46|
|[[:human genes:c:coa6|COA6]]|0.457|
|[[:human genes:t:tfb1m|TFB1M]]|0.457|
|[[:human genes:r:rars2|RARS2]]|0.456|
|[[:human genes:m:mrps27|MRPS27]]|0.456|
|[[:human genes:n:nubpl|NUBPL]]|0.454|
|[[:human genes:c:cox11|COX11]]|0.453|
|[[:human genes:m:mrps12|MRPS12]]|0.452|
|[[:human genes:m:mrpl43|MRPL43]]|0.452|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.451|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.447|
|[[:human genes:m:mrpl39|MRPL39]]|0.445|
|[[:human genes:n:ndufb6|NDUFB6]]|0.445|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.445|
|[[:human genes:m:mrps21|MRPS21]]|0.445|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.444|
|[[:human genes:n:ndufs5|NDUFS5]]|0.443|
|[[:human genes:m:mrps25|MRPS25]]|0.443|
|[[:human genes:m:mrps35|MRPS35]]|0.442|
|[[:human genes:m:mrpl20|MRPL20]]|0.439|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.438|
|[[:human genes:r:rpusd4|RPUSD4]]|0.437|
|[[:human genes:n:ndufc2|NDUFC2]]|0.437|
|[[:human genes:n:ndufa3|NDUFA3]]|0.437|
|[[:human genes:m:mrps18b|MRPS18B]]|0.437|
|[[:human genes:n:ndufv2|NDUFV2]]|0.434|
|[[:human genes:m:mtg1|MTG1]]|0.433|
|[[:human genes:m:mrpl23|MRPL23]]|0.433|
|[[:human genes:w:wars2|WARS2]]|0.432|
|[[:human genes:n:ndufa10|NDUFA10]]|0.431|
|[[:human genes:c:cox6a1|COX6A1]]|0.431|
|[[:human genes:c:c1qbp|C1QBP]]|0.431|
|[[:human genes:s:selrc1|SELRC1]]|0.43|
|[[:human genes:m:mrpl18|MRPL18]]|0.43|
|[[:human genes:e:ecsit|ECSIT]]|0.43|
|[[:human genes:m:mrps7|MRPS7]]|0.43|
|[[:human genes:n:ndufb7|NDUFB7]]|0.43|
|[[:human genes:g:gfm1|GFM1]]|0.428|
|[[:human genes:m:mrpl13|MRPL13]]|0.427|
|[[:human genes:m:mrps34|MRPS34]]|0.426|
|[[:human genes:n:ndufa11|NDUFA11]]|0.425|
|[[:human genes:m:mtg2|MTG2]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.42|
|[[:human genes:m:mrps10|MRPS10]]|0.418|
|[[:human genes:w:wbscr16|WBSCR16]]|0.417|
|[[:human genes:m:mterfd1|MTERFD1]]|0.416|
|[[:human genes:t:tomm7|TOMM7]]|0.416|
|[[:human genes:m:mrpl44|MRPL44]]|0.415|
|[[:human genes:n:ndufb4|NDUFB4]]|0.413|
|[[:human genes:p:pdss2|PDSS2]]|0.413|
|[[:human genes:p:polg2|POLG2]]|0.413|
|[[:human genes:n:ndufa2|NDUFA2]]|0.413|
|[[:human genes:c:cluh|CLUH]]|0.412|
|[[:human genes:m:mcur1|MCUR1]]|0.412|
|[[:human genes:s:sco2|SCO2]]|0.411|
|[[:human genes:c:clpp|CLPP]]|0.409|
|[[:human genes:m:mrp63|MRP63]]|0.408|
|[[:human genes:y:yars2|YARS2]]|0.408|
|[[:human genes:n:ndufc1|NDUFC1]]|0.408|
|[[:human genes:s:slc30a9|SLC30A9]]|0.408|
|[[:human genes:m:mrpl24|MRPL24]]|0.408|
|[[:human genes:t:tars2|TARS2]]|0.407|
|[[:human genes:m:mrpl21|MRPL21]]|0.407|
|[[:human genes:m:mrpl48|MRPL48]]|0.407|
|[[:human genes:m:mrpl12|MRPL12]]|0.406|
|[[:human genes:r:rexo2|REXO2]]|0.406|
|[[:human genes:s:ssbp1|SSBP1]]|0.405|
|[[:human genes:s:sfxn4|SFXN4]]|0.405|
|[[:human genes:m:mrpl1|MRPL1]]|0.405|
|[[:human genes:t:tfb2m|TFB2M]]|0.404|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.404|
|[[:human genes:t:timm8b|TIMM8B]]|0.403|
|[[:human genes:n:ndufv1|NDUFV1]]|0.403|
|[[:human genes:i:ict1|ICT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 799
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERAL1 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>