======= EXOSC10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOSC10
  * **<color #00a2e8>Official Name</color>**: exosome component 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5394|5394]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01780|Q01780]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOSC10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOSC10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRDC|
|DNA pol A exo1|
|PMC2NT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear polyadenylation-dependent CUT catabolic process|
|snRNA catabolic process|
|nuclear polyadenylation-dependent antisense transcript catabolic process|
|antisense RNA metabolic process|
|nuclear polyadenylation-dependent snRNA catabolic process|
|nuclear polyadenylation-dependent snoRNA catabolic process|
|antisense RNA transcript catabolic process|
|snoRNA catabolic process|
|nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|
|nuclear retention of unspliced pre-mRNA at the site of transcription|
|CUT metabolic process|
|CUT catabolic process|
|nuclear ncRNA surveillance|
|nuclear retention of pre-mRNA at the site of transcription|
|nuclear polyadenylation-dependent rRNA catabolic process|
|nuclear polyadenylation-dependent tRNA catabolic process|
|nuclear polyadenylation-dependent ncRNA catabolic process|
|polyadenylation-dependent ncRNA catabolic process|
|polyadenylation-dependent snoRNA 3-end processing|
|exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|polyadenylation-dependent RNA catabolic process|
|exonucleolytic trimming involved in rRNA processing|
|tRNA catabolic process|
|rRNA 3-end processing|
|intracellular mRNA localization|
|snoRNA 3-end processing|
|snoRNA processing|
|nuclear RNA surveillance|
|exoribonuclease activity|
|nuclear mRNA surveillance|
|histone mRNA catabolic process|
|RNA surveillance|
|dosage compensation by inactivation of X chromosome|
|nuclear exosome (RNase complex)|
|snoRNA metabolic process|
|exosome (RNase complex)|
|regulation of telomerase RNA localization to Cajal body|
|dosage compensation|
|rRNA catabolic process|
|negative regulation of telomere maintenance via telomerase|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|telomerase RNA binding|
|transcriptionally active chromatin|
|negative regulation of telomere maintenance via telomere lengthening|
|maturation of 5.8S rRNA|
|ncRNA catabolic process|
|histone mRNA metabolic process|
|3-5-exoribonuclease activity|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|snRNA metabolic process|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|single-stranded RNA binding|
|ncRNA 3-end processing|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|nucleotide binding|
|regulation of telomere maintenance|
|regulation of DNA biosynthetic process|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|RNA localization|
|rRNA metabolic process|
|regulation of gene expression, epigenetic|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|modification-dependent macromolecule catabolic process|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular macromolecule localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.98|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 492/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|14/28|
|bone|15/26|
|breast|19/33|
|central nervous system|39/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|15/21|
|liver|12/20|
|lung|50/75|
|lymphocyte|3/16|
|ovary|18/26|
|pancreas|18/24|
|peripheral nervous system|11/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|20/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOSC10 Expression in NALM6 Cells: 7.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>