======= FAM101B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFLNB
  * **<color #00a2e8>Official Name</color>**: refilin B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=359845|359845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5W9|Q8N5W9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM101B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM101B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. {ECO:0000250|UniProtKB:Q5SVD0}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of chondrocyte development|
|regulation of chondrocyte development|
|negative regulation of bone mineralization involved in bone maturation|
|regulation of bone mineralization involved in bone maturation|
|actin filament bundle|
|negative regulation of bone development|
|filamin binding|
|negative regulation of bone mineralization|
|negative regulation of chondrocyte differentiation|
|regulation of bone development|
|negative regulation of biomineral tissue development|
|negative regulation of biomineralization|
|negative regulation of cartilage development|
|regulation of chondrocyte differentiation|
|actin filament bundle organization|
|epithelial to mesenchymal transition|
|regulation of cartilage development|
|negative regulation of ossification|
|regulation of bone mineralization|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|mesenchymal cell differentiation|
|regulation of ossification|
|mesenchyme development|
|skeletal system morphogenesis|
|actin filament organization|
|negative regulation of cell development|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|skeletal system development|
|actin filament-based process|
|negative regulation of cell differentiation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cytoskeleton organization|
|negative regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM101B Expression in NALM6 Cells: 0.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>