======= FAM122A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM122A
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 122A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116224|116224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96E09|Q96E09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM122A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM122A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein serine/threonine phosphatase inhibitor activity|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of protein dephosphorylation|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of cell growth|
|regulation of phosphatase activity|
|regulation of proteasomal protein catabolic process|
|regulation of dephosphorylation|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|positive regulation of growth|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of cell growth|
|positive regulation of catabolic process|
|negative regulation of hydrolase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of growth|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.68|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.68|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.51|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.37|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.24|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.16|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.12|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.01|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.9|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.85|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.85|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.8|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.79|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.78|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.75|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.72|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.72|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.79|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.89|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.96|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.07|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.48|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.51|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.51|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.54|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.72|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|3.03|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.15|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|3.38|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|3.42|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|3.6|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.85|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|4.29|
|[[:results:exp504|MK2206 4μM R08 exp504]]|5|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|5.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tsc2|TSC2]]|0.491|
|[[:human genes:c:cdk8|CDK8]]|0.472|
|[[:human genes:m:memo1|MEMO1]]|0.463|
|[[:human genes:t:tsc1|TSC1]]|0.457|
|[[:human genes:t:tbc1d7|TBC1D7]]|0.453|
|[[:human genes:c:cnot8|CNOT8]]|0.449|
|[[:human genes:i:ipo11|IPO11]]|0.448|
|[[:human genes:c:cnot2|CNOT2]]|0.448|
|[[:human genes:z:znf148|ZNF148]]|0.445|
|[[:human genes:k:kdm6a|KDM6A]]|0.441|
|[[:human genes:g:gskip|GSKIP]]|0.438|
|[[:human genes:c:cramp1l|CRAMP1L]]|0.435|
|[[:human genes:z:zbtb14|ZBTB14]]|0.432|
|[[:human genes:r:rrm1|RRM1]]|0.428|
|[[:human genes:f:fkbp1a|FKBP1A]]|0.427|
|[[:human genes:a:anp32a|ANP32A]]|0.423|
|[[:human genes:p:plcg2|PLCG2]]|0.416|
|[[:human genes:y:ypel5|YPEL5]]|0.414|
|[[:human genes:n:nprl2|NPRL2]]|0.414|
|[[:human genes:q:qki|QKI]]|0.411|
|[[:human genes:r:rbm38|RBM38]]|0.404|
|[[:human genes:g:gsk3b|GSK3B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM122A Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>