======= FAM132A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1QTNF12
  * **<color #00a2e8>Official Name</color>**: C1q and TNF related 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388581|388581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T7M4|Q5T7M4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM132A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM132A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. {ECO:0000250|UniProtKB:Q8R2Z0}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of gluconeogenesis|
|positive regulation of insulin receptor signaling pathway|
|positive regulation of cellular response to insulin stimulus|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of glucose import|
|negative regulation of cellular carbohydrate metabolic process|
|positive regulation of glucose transmembrane transport|
|regulation of gluconeogenesis|
|negative regulation of carbohydrate metabolic process|
|regulation of glucose import|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of insulin receptor signaling pathway|
|positive regulation of insulin secretion|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|positive regulation of peptide hormone secretion|
|hormone activity|
|regulation of glucose metabolic process|
|positive regulation of hormone secretion|
|negative regulation of inflammatory response|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of protein kinase B signaling|
|regulation of insulin secretion|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|regulation of peptide hormone secretion|
|regulation of protein kinase B signaling|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of transmembrane transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|regulation of cellular localization|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|regulation of response to external stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM132A Expression in NALM6 Cells: -1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>