======= FAM20A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM20A
  * **<color #00a2e8>Official Name</color>**: FAM20A golgi associated secretory pathway pseudokinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54757|54757]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MK3|Q96MK3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM20A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM20A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611062|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a protein that is likely secreted and may function in hematopoiesis. A mutation at this locus has been associated with amelogenesis imperfecta and gingival hyperplasia syndrome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. {ECO:0000269|PubMed:25789606}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1193|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphotransferase activity, alcohol group as acceptor|
|tooth eruption|
|enamel mineralization|
|tooth mineralization|
|amelogenesis|
|protein serine/threonine kinase activator activity|
|cell|
|odontogenesis of dentin-containing tooth|
|biomineralization|
|biomineral tissue development|
|odontogenesis|
|positive regulation of protein serine/threonine kinase activity|
|protein serine/threonine kinase activity|
|calcium ion homeostasis|
|divalent inorganic cation homeostasis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|metal ion homeostasis|
|positive regulation of transferase activity|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|1.7|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.55|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.466|
|[[:human genes:c:cope|COPE]]|0.461|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.458|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.457|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.452|
|[[:human genes:f:fam231a|FAM231A]]|0.45|
|[[:human genes:f:fam231c|FAM231C]]|0.45|
|[[:human genes:s:supt5h|SUPT5H]]|0.449|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.445|
|[[:human genes:c:chd4|CHD4]]|0.441|
|[[:human genes:t:tfip11|TFIP11]]|0.438|
|[[:human genes:p:psmd3|PSMD3]]|0.438|
|[[:human genes:e:exosc9|EXOSC9]]|0.435|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.433|
|[[:human genes:t:tceb3c|TCEB3C]]|0.43|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:v:vps28|VPS28]]|0.429|
|[[:human genes:c:c14orf93|C14orf93]]|0.428|
|[[:human genes:c:ckap5|CKAP5]]|0.427|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.422|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.422|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.422|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.419|
|[[:human genes:p:psma7|PSMA7]]|0.419|
|[[:human genes:p:psmb4|PSMB4]]|0.414|
|[[:human genes:m:mat2a|MAT2A]]|0.412|
|[[:human genes:c:cbwd3|CBWD3]]|0.407|
|[[:human genes:s:s1pr4|S1PR4]]|0.406|
|[[:human genes:m:mt1e|MT1E]]|0.404|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:c:cdc73|CDC73]]|0.401|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.401|
|[[:human genes:p:psmc5|PSMC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM20A Expression in NALM6 Cells: 0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>