======= FAM20C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM20C
  * **<color #00a2e8>Official Name</color>**: FAM20C golgi associated secretory pathway kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56975|56975]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXL6|Q8IXL6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM20C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM20C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). {ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606, ECO:0000269|PubMed:26091039}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1193|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osteoclast maturation|
|odontoblast differentiation|
|phosphotransferase activity, alcohol group as acceptor|
|dentinogenesis|
|osteoclast development|
|enamel mineralization|
|tooth mineralization|
|amelogenesis|
|bone cell development|
|regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of bone mineralization|
|neuroepithelial cell differentiation|
|osteoclast differentiation|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|positive regulation of osteoblast differentiation|
|myeloid cell development|
|manganese ion binding|
|regulation of bone mineralization|
|odontogenesis of dentin-containing tooth|
|positive regulation of ossification|
|biomineral tissue development|
|biomineralization|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|columnar/cuboidal epithelial cell differentiation|
|myeloid leukocyte differentiation|
|regulation of osteoblast differentiation|
|odontogenesis|
|anatomical structure maturation|
|cell maturation|
|regulation of ossification|
|bone development|
|ATP metabolic process|
|myeloid cell differentiation|
|developmental maturation|
|regulation of cellular response to growth factor stimulus|
|endoplasmic reticulum lumen|
|leukocyte differentiation|
|post-translational protein modification|
|protein serine/threonine kinase activity|
|skeletal system development|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|epithelial cell differentiation|
|calcium ion binding|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|Golgi apparatus|
|epithelium development|
|phosphorylation|
|positive regulation of developmental process|
|ATP binding|
|extracellular space|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM20C Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>