======= FAM210B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM210B
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 210 member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116151|116151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KR6|Q96KR6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM210B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM210B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618722|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398). {ECO:0000269|PubMed:26968549, ECO:0000269|PubMed:28594398}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1279|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic component of membrane|
|erythrocyte maturation|
|positive regulation of erythrocyte differentiation|
|erythrocyte development|
|cellular response to estradiol stimulus|
|regulation of erythrocyte differentiation|
|myeloid cell development|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|myeloid cell homeostasis|
|anatomical structure maturation|
|response to estradiol|
|cell maturation|
|mitochondrial outer membrane|
|positive regulation of hemopoiesis|
|homeostasis of number of cells|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|developmental maturation|
|regulation of hemopoiesis|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|hemopoiesis|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|cellular response to oxygen-containing compound|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14009
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM210B Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>