======= FAM96B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIAO2B
  * **<color #00a2e8>Official Name</color>**: cytosolic iron-sulfur assembly component 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51647|51647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D0|Q9Y3D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM96B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM96B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. {ECO:0000269|PubMed:20797633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF59|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CIA complex|
|protein maturation by [4Fe-4S] cluster transfer|
|MMXD complex|
|protein maturation by iron-sulfur cluster transfer|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|spindle|
|cofactor biosynthetic process|
|protein maturation|
|chromosome segregation|
|sulfur compound metabolic process|
|cofactor metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.33|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.93|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.9|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.83|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.72|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.84|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|3.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:glrx3|GLRX3]]|0.481|
|[[:human genes:m:mms19|MMS19]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 687/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|26/28|
|blood|23/28|
|bone|26/26|
|breast|28/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|20/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM96B Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>