======= FANCA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FANCA
  * **<color #00a2e8>Official Name</color>**: FA complementation group A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2175|2175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15360|O15360]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FANCA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FANCA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fanconi A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of CD40 signaling pathway|
|Fanconi anaemia nuclear complex|
|regulation of regulatory T cell differentiation|
|male meiotic nuclear division|
|interstrand cross-link repair|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of T cell differentiation|
|meiotic nuclear division|
|male sex differentiation|
|meiotic cell cycle process|
|regulation of lymphocyte differentiation|
|gonad development|
|development of primary sexual characteristics|
|meiotic cell cycle|
|sex differentiation|
|regulation of leukocyte differentiation|
|nuclear division|
|organelle fission|
|regulation of T cell activation|
|regulation of inflammatory response|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|regulation of hemopoiesis|
|DNA repair|
|regulation of lymphocyte activation|
|male gamete generation|
|regulation of leukocyte activation|
|regulation of cell activation|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|regulation of response to external stimulus|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|regulation of immune system process|
|cellular response to stress|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.94|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.93|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.76|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c17orf70|C17orf70]]|0.51|
|[[:human genes:f:fance|FANCE]]|0.504|
|[[:human genes:f:fancc|FANCC]]|0.45|
|[[:human genes:f:fancd2|FANCD2]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 888
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FANCA Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>