======= FANCG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FANCG
  * **<color #00a2e8>Official Name</color>**: FA complementation group G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2189|2189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15287|O15287]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FANCG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FANCG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602956|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Fanconi anaemia nuclear complex|
|ovarian follicle development|
|interstrand cross-link repair|
|damaged DNA binding|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|spermatid development|
|spermatid differentiation|
|gonad development|
|development of primary sexual characteristics|
|germ cell development|
|sex differentiation|
|cellular process involved in reproduction in multicellular organism|
|reproductive structure development|
|reproductive system development|
|response to radiation|
|mitochondrion organization|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|multi-organism reproductive process|
|response to abiotic stimulus|
|mitochondrion|
|reproductive process|
|reproduction|
|cell development|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.96|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.83|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fancf|FANCF]]|0.482|
|[[:human genes:f:fancd2|FANCD2]]|0.455|
|[[:human genes:f:fance|FANCE]]|0.442|
|[[:human genes:c:c17orf70|C17orf70]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FANCG Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>