======= FARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FARS2
  * **<color #00a2e8>Official Name</color>**: phenylalanyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10667|10667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95363|O95363]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611592|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. {ECO:0000269|PubMed:19549855, ECO:0000269|PubMed:22833457}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FDX-ACB|
|tRNA-synt 2d|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phenylalanyl-tRNA aminoacylation|
|phenylalanine-tRNA ligase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA processing|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|RNA processing|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.52|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.94|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.88|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.73|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.83|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.86|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.96|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.97|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.04|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.06|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.648|
|[[:human genes:d:dars2|DARS2]]|0.629|
|[[:human genes:s:sco2|SCO2]]|0.612|
|[[:human genes:r:rpusd4|RPUSD4]]|0.612|
|[[:human genes:d:dap3|DAP3]]|0.611|
|[[:human genes:q:qrsl1|QRSL1]]|0.607|
|[[:human genes:y:yars2|YARS2]]|0.606|
|[[:human genes:m:mrps5|MRPS5]]|0.599|
|[[:human genes:g:gfm1|GFM1]]|0.597|
|[[:human genes:v:vars2|VARS2]]|0.594|
|[[:human genes:c:coa3|COA3]]|0.59|
|[[:human genes:m:mrpl23|MRPL23]]|0.589|
|[[:human genes:s:selrc1|SELRC1]]|0.588|
|[[:human genes:m:mrp63|MRP63]]|0.588|
|[[:human genes:m:mrps34|MRPS34]]|0.586|
|[[:human genes:c:cox16|COX16]]|0.582|
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:m:mrps25|MRPS25]]|0.58|
|[[:human genes:m:mrps6|MRPS6]]|0.572|
|[[:human genes:m:mrps2|MRPS2]]|0.571|
|[[:human genes:b:bcs1l|BCS1L]]|0.57|
|[[:human genes:m:mrps14|MRPS14]]|0.569|
|[[:human genes:m:mrps26|MRPS26]]|0.567|
|[[:human genes:m:mrps12|MRPS12]]|0.561|
|[[:human genes:m:mrps16|MRPS16]]|0.561|
|[[:human genes:c:c10orf2|C10orf2]]|0.56|
|[[:human genes:t:tars2|TARS2]]|0.559|
|[[:human genes:s:sars2|SARS2]]|0.559|
|[[:human genes:m:mrps21|MRPS21]]|0.556|
|[[:human genes:n:nars2|NARS2]]|0.555|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.552|
|[[:human genes:e:ears2|EARS2]]|0.546|
|[[:human genes:p:pars2|PARS2]]|0.545|
|[[:human genes:t:tufm|TUFM]]|0.545|
|[[:human genes:m:mrpl47|MRPL47]]|0.541|
|[[:human genes:m:mrps18a|MRPS18A]]|0.537|
|[[:human genes:a:aars2|AARS2]]|0.537|
|[[:human genes:t:trub2|TRUB2]]|0.532|
|[[:human genes:m:mrpl18|MRPL18]]|0.53|
|[[:human genes:m:mrps23|MRPS23]]|0.529|
|[[:human genes:m:mars2|MARS2]]|0.525|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.525|
|[[:human genes:n:ndufa3|NDUFA3]]|0.523|
|[[:human genes:s:slc25a26|SLC25A26]]|0.522|
|[[:human genes:f:ftsj2|FTSJ2]]|0.52|
|[[:human genes:n:ndufb6|NDUFB6]]|0.518|
|[[:human genes:l:lars2|LARS2]]|0.518|
|[[:human genes:m:mrpl15|MRPL15]]|0.518|
|[[:human genes:r:rars2|RARS2]]|0.517|
|[[:human genes:m:mrps24|MRPS24]]|0.516|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.516|
|[[:human genes:c:cox7b|COX7B]]|0.516|
|[[:human genes:r:rbfa|RBFA]]|0.512|
|[[:human genes:f:fastkd5|FASTKD5]]|0.512|
|[[:human genes:i:iba57|IBA57]]|0.511|
|[[:human genes:c:coa5|COA5]]|0.511|
|[[:human genes:w:wbscr16|WBSCR16]]|0.51|
|[[:human genes:n:ndufb11|NDUFB11]]|0.508|
|[[:human genes:m:mrpl53|MRPL53]]|0.505|
|[[:human genes:c:cox11|COX11]]|0.505|
|[[:human genes:m:mrpl3|MRPL3]]|0.5|
|[[:human genes:m:mrpl33|MRPL33]]|0.499|
|[[:human genes:m:mrpl55|MRPL55]]|0.498|
|[[:human genes:h:hars2|HARS2]]|0.498|
|[[:human genes:m:mrps22|MRPS22]]|0.496|
|[[:human genes:p:pet112|PET112]]|0.495|
|[[:human genes:m:mrpl4|MRPL4]]|0.494|
|[[:human genes:m:mrps7|MRPS7]]|0.494|
|[[:human genes:m:mrpl44|MRPL44]]|0.49|
|[[:human genes:m:mtg2|MTG2]]|0.49|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.49|
|[[:human genes:c:cox6b1|COX6B1]]|0.488|
|[[:human genes:n:ndufs7|NDUFS7]]|0.487|
|[[:human genes:c:coa6|COA6]]|0.486|
|[[:human genes:e:elac2|ELAC2]]|0.486|
|[[:human genes:m:mtg1|MTG1]]|0.483|
|[[:human genes:m:mrpl12|MRPL12]]|0.48|
|[[:human genes:t:tfam|TFAM]]|0.48|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.48|
|[[:human genes:g:gfm2|GFM2]]|0.478|
|[[:human genes:m:mrpl20|MRPL20]]|0.478|
|[[:human genes:c:cox6c|COX6C]]|0.478|
|[[:human genes:t:tefm|TEFM]]|0.477|
|[[:human genes:m:mettl17|METTL17]]|0.477|
|[[:human genes:p:polg2|POLG2]]|0.476|
|[[:human genes:m:mrpl13|MRPL13]]|0.476|
|[[:human genes:c:c17orf89|C17orf89]]|0.476|
|[[:human genes:p:pnpt1|PNPT1]]|0.474|
|[[:human genes:c:c12orf65|C12orf65]]|0.473|
|[[:human genes:m:mipep|MIPEP]]|0.473|
|[[:human genes:p:pet117|PET117]]|0.472|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.471|
|[[:human genes:m:mrpl36|MRPL36]]|0.47|
|[[:human genes:c:cox15|COX15]]|0.468|
|[[:human genes:c:chchd1|CHCHD1]]|0.465|
|[[:human genes:m:mrps35|MRPS35]]|0.462|
|[[:human genes:r:rpusd3|RPUSD3]]|0.462|
|[[:human genes:m:mrps27|MRPS27]]|0.461|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.461|
|[[:human genes:m:mrps9|MRPS9]]|0.461|
|[[:human genes:c:cox17|COX17]]|0.459|
|[[:human genes:n:ndufs2|NDUFS2]]|0.459|
|[[:human genes:m:mrpl27|MRPL27]]|0.458|
|[[:human genes:u:uqcr10|UQCR10]]|0.457|
|[[:human genes:m:mtpap|MTPAP]]|0.456|
|[[:human genes:n:ndufv1|NDUFV1]]|0.455|
|[[:human genes:m:mrps10|MRPS10]]|0.452|
|[[:human genes:a:aifm1|AIFM1]]|0.452|
|[[:human genes:n:ndufa2|NDUFA2]]|0.451|
|[[:human genes:m:mrpl32|MRPL32]]|0.45|
|[[:human genes:m:mrpl46|MRPL46]]|0.449|
|[[:human genes:g:gatc|GATC]]|0.448|
|[[:human genes:m:mrps33|MRPS33]]|0.447|
|[[:human genes:m:mrpl52|MRPL52]]|0.446|
|[[:human genes:m:mrpl43|MRPL43]]|0.445|
|[[:human genes:h:higd2a|HIGD2A]]|0.444|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.444|
|[[:human genes:m:mrpl2|MRPL2]]|0.444|
|[[:human genes:n:ndufa1|NDUFA1]]|0.444|
|[[:human genes:l:lrpprc|LRPPRC]]|0.441|
|[[:human genes:t:tmem242|TMEM242]]|0.44|
|[[:human genes:m:mrpl42|MRPL42]]|0.439|
|[[:human genes:a:atp5c1|ATP5C1]]|0.439|
|[[:human genes:m:mrpl45|MRPL45]]|0.439|
|[[:human genes:p:polrmt|POLRMT]]|0.438|
|[[:human genes:c:cox5a|COX5A]]|0.438|
|[[:human genes:m:mrps11|MRPS11]]|0.437|
|[[:human genes:c:coq2|COQ2]]|0.436|
|[[:human genes:g:glrx5|GLRX5]]|0.436|
|[[:human genes:p:polg|POLG]]|0.435|
|[[:human genes:m:mtif3|MTIF3]]|0.432|
|[[:human genes:m:mrpl49|MRPL49]]|0.431|
|[[:human genes:m:mrpl38|MRPL38]]|0.43|
|[[:human genes:c:coq4|COQ4]]|0.427|
|[[:human genes:w:wars2|WARS2]]|0.424|
|[[:human genes:e:ecsit|ECSIT]]|0.423|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.423|
|[[:human genes:n:ndufb5|NDUFB5]]|0.423|
|[[:human genes:n:ndufb9|NDUFB9]]|0.423|
|[[:human genes:p:pdss1|PDSS1]]|0.422|
|[[:human genes:m:mrpl39|MRPL39]]|0.422|
|[[:human genes:n:ndufb3|NDUFB3]]|0.421|
|[[:human genes:m:mterfd1|MTERFD1]]|0.421|
|[[:human genes:m:mrpl17|MRPL17]]|0.421|
|[[:human genes:n:ndufa11|NDUFA11]]|0.42|
|[[:human genes:n:ndufc2|NDUFC2]]|0.419|
|[[:human genes:m:mrpl9|MRPL9]]|0.419|
|[[:human genes:d:dhx30|DHX30]]|0.418|
|[[:human genes:m:mrps28|MRPS28]]|0.418|
|[[:human genes:a:acad9|ACAD9]]|0.415|
|[[:human genes:t:tomm20|TOMM20]]|0.414|
|[[:human genes:m:mrpl34|MRPL34]]|0.414|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.414|
|[[:human genes:n:nfu1|NFU1]]|0.413|
|[[:human genes:c:cars2|CARS2]]|0.413|
|[[:human genes:n:ndufc1|NDUFC1]]|0.409|
|[[:human genes:m:mrpl24|MRPL24]]|0.407|
|[[:human genes:c:cox4i1|COX4I1]]|0.406|
|[[:human genes:m:mrpl37|MRPL37]]|0.404|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.401|
|[[:human genes:t:tpk1|TPK1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 94/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|7/28|
|bone|2/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|4/20|
|lung|17/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FARS2 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>