======= FASLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FASLG
  * **<color #00a2e8>Official Name</color>**: Fas ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=356|356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48023|P48023]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FASLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FASLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134638|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). {ECO:0000250|UniProtKB:P41047, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:27806260, ECO:0000269|PubMed:7528780, ECO:0000269|PubMed:9228058, ECO:0000269|PubMed:9427603}. FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition. {ECO:0000269|PubMed:17557115}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal cell programmed cell death|
|endosomal lumen acidification|
|cellular chloride ion homeostasis|
|cytoplasmic vesicle lumen|
|necroptotic signaling pathway|
|inflammatory cell apoptotic process|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|programmed cell death involved in cell development|
|cellular monovalent inorganic anion homeostasis|
|cellular anion homeostasis|
|T cell apoptotic process|
|chloride ion homeostasis|
|death receptor binding|
|lymphocyte apoptotic process|
|positive regulation of endothelial cell apoptotic process|
|necroptotic process|
|leukocyte apoptotic process|
|monovalent inorganic anion homeostasis|
|programmed necrotic cell death|
|necrotic cell death|
|tumor necrosis factor receptor binding|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of epithelial cell apoptotic process|
|positive regulation of ERBB signaling pathway|
|extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|intracellular pH reduction|
|pH reduction|
|regulation of endothelial cell apoptotic process|
|positive regulation of neuron apoptotic process|
|release of sequestered calcium ion into cytosol|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of sequestering of calcium ion|
|anion homeostasis|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|caveola|
|endosome organization|
|regulation of epithelial cell apoptotic process|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of intracellular pH|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|cytosolic calcium ion transport|
|regulation of cellular pH|
|regulation of ERBB signaling pathway|
|positive regulation of neuron death|
|lysosomal lumen|
|extrinsic apoptotic signaling pathway|
|regulation of pH|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|cellular monovalent inorganic cation homeostasis|
|negative regulation of vasculature development|
|regulation of sequestering of calcium ion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|monovalent inorganic cation homeostasis|
|eye morphogenesis|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of endopeptidase activity|
|cytokine activity|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidase activity|
|calcium ion transmembrane transport|
|regulation of neuron apoptotic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|calcium ion transport|
|sensory organ morphogenesis|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|divalent metal ion transport|
|vesicle organization|
|divalent inorganic cation transport|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|positive regulation of proteolysis|
|eye development|
|visual system development|
|sensory system development|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|regulation of peptidase activity|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to growth factor|
|sensory organ development|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|response to bacterium|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FASLG Expression in NALM6 Cells: -0.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>