======= FASTKD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FASTKD1
  * **<color #00a2e8>Official Name</color>**: FAST kinase domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79675|79675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53R41|Q53R41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FASTKD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FASTKD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617529|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the stability of mitochondrial MT-ND3 mRNA (PubMed:28335001). {ECO:0000269|PubMed:28335001}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RAP|
|FAST 2|
|FAST 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of mitochondrial mRNA stability|
|mitochondrial RNA metabolic process|
|cellular respiration|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|energy derivation by oxidation of organic compounds|
|protein kinase activity|
|regulation of mRNA metabolic process|
|generation of precursor metabolites and energy|
|posttranscriptional regulation of gene expression|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of catabolic process|
|mitochondrion|
|phosphorylation|
|RNA binding|
|RNA metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-3.35|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-2.1|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.92|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.96|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.98|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.06|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.53|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.61|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ears2|EARS2]]|0.484|
|[[:human genes:q:qrsl1|QRSL1]]|0.467|
|[[:human genes:s:selrc1|SELRC1]]|0.457|
|[[:human genes:m:mrps6|MRPS6]]|0.456|
|[[:human genes:s:sars2|SARS2]]|0.451|
|[[:human genes:c:coa3|COA3]]|0.449|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.444|
|[[:human genes:w:wbscr16|WBSCR16]]|0.442|
|[[:human genes:c:coa6|COA6]]|0.441|
|[[:human genes:m:mrps18a|MRPS18A]]|0.44|
|[[:human genes:n:ndufb11|NDUFB11]]|0.438|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.437|
|[[:human genes:p:pet117|PET117]]|0.436|
|[[:human genes:m:mrpl11|MRPL11]]|0.436|
|[[:human genes:c:c12orf65|C12orf65]]|0.433|
|[[:human genes:t:tars2|TARS2]]|0.432|
|[[:human genes:n:nars2|NARS2]]|0.432|
|[[:human genes:m:mrps5|MRPS5]]|0.432|
|[[:human genes:m:mrpl21|MRPL21]]|0.431|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.431|
|[[:human genes:g:gfm1|GFM1]]|0.431|
|[[:human genes:b:bcs1l|BCS1L]]|0.43|
|[[:human genes:c:coq2|COQ2]]|0.43|
|[[:human genes:r:rars2|RARS2]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.429|
|[[:human genes:p:polg|POLG]]|0.42|
|[[:human genes:m:mrps34|MRPS34]]|0.42|
|[[:human genes:p:pitrm1|PITRM1]]|0.417|
|[[:human genes:p:pet112|PET112]]|0.416|
|[[:human genes:m:mrpl15|MRPL15]]|0.415|
|[[:human genes:m:mrps21|MRPS21]]|0.414|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.412|
|[[:human genes:p:pars2|PARS2]]|0.412|
|[[:human genes:n:ndufa2|NDUFA2]]|0.411|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.41|
|[[:human genes:d:dap3|DAP3]]|0.41|
|[[:human genes:d:ddx28|DDX28]]|0.41|
|[[:human genes:m:mto1|MTO1]]|0.408|
|[[:human genes:w:wars2|WARS2]]|0.407|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.405|
|[[:human genes:m:mrp63|MRP63]]|0.404|
|[[:human genes:y:yars2|YARS2]]|0.403|
|[[:human genes:c:cox7b|COX7B]]|0.403|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10226
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FASTKD1 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>