======= FECH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FECH
  * **<color #00a2e8>Official Name</color>**: ferrochelatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2235|2235]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22830|P22830]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FECH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FECH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the ferrous insertion into protoporphyrin IX.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferrochelatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ferrochelatase activity|
|protoporphyrinogen IX metabolic process|
|2 iron, 2 sulfur cluster binding|
|heme biosynthetic process|
|ferrous iron binding|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|cofactor biosynthetic process|
|response to light stimulus|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|response to radiation|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.17|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.04|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.88|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.84|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.74|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.74|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.76|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.77|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.87|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.95|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.07|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.13|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.18|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.25|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.29|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.56|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.58|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.7|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.84|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.88|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|6.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alas1|ALAS1]]|0.743|
|[[:human genes:h:hmbs|HMBS]]|0.528|
|[[:human genes:b:bak1|BAK1]]|0.511|
|[[:human genes:h:hccs|HCCS]]|0.496|
|[[:human genes:m:march5|MARCH5]]|0.496|
|[[:human genes:a:alad|ALAD]]|0.45|
|[[:human genes:a:apaf1|APAF1]]|0.447|
|[[:human genes:d:dohh|DOHH]]|0.44|
|[[:human genes:m:mrpl21|MRPL21]]|0.438|
|[[:human genes:c:casp9|CASP9]]|0.435|
|[[:human genes:p:ppox|PPOX]]|0.433|
|[[:human genes:v:vdac2|VDAC2]]|0.433|
|[[:human genes:c:cycs|CYCS]]|0.427|
|[[:human genes:c:cpox|CPOX]]|0.42|
|[[:human genes:c:cept1|CEPT1]]|0.414|
|[[:human genes:k:kdsr|KDSR]]|0.413|
|[[:human genes:c:coq3|COQ3]]|0.412|
|[[:human genes:p:plaa|PLAA]]|0.412|
|[[:human genes:t:tufm|TUFM]]|0.411|
|[[:human genes:r:romo1|ROMO1]]|0.406|
|[[:human genes:s:serf2|SERF2]]|0.404|
|[[:human genes:n:nars2|NARS2]]|0.403|
|[[:human genes:g:glrx5|GLRX5]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1605
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FECH Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>