======= FKBP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP5
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2289|2289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13451|Q13451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602623|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FKBP C|
|TPR 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FK506 binding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|heat shock protein binding|
|chaperone-mediated protein folding|
|peptidyl-proline modification|
|protein folding|
|response to bacterium|
|peptidyl-amino acid modification|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-3.29|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.68|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.24|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.19|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.18|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.18|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.17|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.05|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.04|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.74|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.73|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.72|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.72|
|[[:results:exp539|42°C R08 exp539]]|1.8|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.83|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.85|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.94|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.97|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.14|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.59|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.61|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:glmn|GLMN]]|0.557|
|[[:human genes:u:ube2g1|UBE2G1]]|0.526|
|[[:human genes:t:tmem161b|TMEM161B]]|0.403|
|[[:human genes:s:sp3|SP3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP5 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>