======= FOXK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXK1
  * **<color #00a2e8>Official Name</color>**: forkhead box K1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=221937|221937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P85037|P85037]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616302|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor cell population (By similarity). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity). Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164). {ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:25852164}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|canonical glycolysis|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|glycolytic process through fructose-6-phosphate|
|glycolytic process through glucose-6-phosphate|
|14-3-3 protein binding|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|regulation of gluconeogenesis|
|NAD metabolic process|
|ADP metabolic process|
|hexose catabolic process|
|nucleoside diphosphate phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|transcription regulatory region sequence-specific DNA binding|
|nucleoside diphosphate metabolic process|
|negative regulation of autophagy|
|cellular glucose homeostasis|
|regulation of carbohydrate biosynthetic process|
|glucose metabolic process|
|regulation of glucose metabolic process|
|carbohydrate catabolic process|
|regulation of cellular carbohydrate metabolic process|
|hexose metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|response to starvation|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|ATP metabolic process|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|negative regulation of cellular catabolic process|
|protein deubiquitination|
|muscle organ development|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|purine ribonucleotide metabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of autophagy|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|muscle structure development|
|response to nutrient levels|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|nucleobase-containing small molecule metabolic process|
|DNA-binding transcription factor activity|
|cellular chemical homeostasis|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|organophosphate metabolic process|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|chemical homeostasis|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.11|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.92|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.86|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.84|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.73|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.73|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.13|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.23|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.28|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.08|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.13|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|3.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|4.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXK1 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>