======= FOXO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXO3
  * **<color #00a2e8>Official Name</color>**: forkhead box O3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2309|2309]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43524|O43524]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial sequence-specific DNA-binding transcription factor activity|
|positive regulation of muscle atrophy|
|initiation of primordial ovarian follicle growth|
|cellular response to corticosterone stimulus|
|regulation of muscle atrophy|
|positive regulation of hydrogen peroxide-mediated programmed cell death|
|response to water-immersion restraint stress|
|positive regulation of hydrogen peroxide-induced cell death|
|cellular response to mineralocorticoid stimulus|
|transcription cofactor binding|
|positive regulation of muscle adaptation|
|antral ovarian follicle growth|
|positive regulation of response to reactive oxygen species|
|regulation of hydrogen peroxide-mediated programmed cell death|
|ovulation from ovarian follicle|
|positive regulation of cellular response to drug|
|mitochondrial transcription|
|positive regulation of oxidative stress-induced cell death|
|positive regulation of cellular response to oxidative stress|
|ovulation|
|positive regulation of endothelial cell apoptotic process|
|positive regulation of response to oxidative stress|
|oocyte maturation|
|response to corticosterone|
|regulation of hydrogen peroxide-induced cell death|
|neuronal stem cell population maintenance|
|response to immobilization stress|
|positive regulation of erythrocyte differentiation|
|signal transduction in absence of ligand|
|positive regulation of response to drug|
|extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of epithelial cell apoptotic process|
|response to mineralocorticoid|
|brain morphogenesis|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|oocyte development|
|cellular response to amyloid-beta|
|mitochondrial RNA metabolic process|
|response to dexamethasone|
|ovulation cycle process|
|oocyte differentiation|
|regulation of erythrocyte differentiation|
|response to amyloid-beta|
|cellular response to nerve growth factor stimulus|
|regulation of endothelial cell apoptotic process|
|positive regulation of reactive oxygen species biosynthetic process|
|ovarian follicle development|
|response to nerve growth factor|
|positive regulation of neuron apoptotic process|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|regulation of oxidative stress-induced cell death|
|ovulation cycle|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|chromatin DNA binding|
|cellular response to monosaccharide stimulus|
|regulation of cellular response to oxidative stress|
|oogenesis|
|regulation of epithelial cell apoptotic process|
|DNA damage response, signal transduction by p53 class mediator|
|cellular response to carbohydrate stimulus|
|beta-catenin binding|
|cellular response to alcohol|
|regulation of response to oxidative stress|
|regulation of muscle adaptation|
|regulation of reactive oxygen species biosynthetic process|
|cellular glucose homeostasis|
|insulin receptor signaling pathway|
|regulation of neural precursor cell proliferation|
|female gonad development|
|positive regulation of neuron death|
|cellular response to ketone|
|positive regulation of myeloid cell differentiation|
|development of primary female sexual characteristics|
|response to antineoplastic agent|
|positive regulation of reactive oxygen species metabolic process|
|extrinsic apoptotic signaling pathway|
|regulation of response to drug|
|signal transduction in response to DNA damage|
|female sex differentiation|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of autophagy|
|signal transduction by p53 class mediator|
|female gamete generation|
|anatomical structure maturation|
|stem cell population maintenance|
|maintenance of cell number|
|response to glucose|
|mitochondrial gene expression|
|response to hexose|
|response to glucocorticoid|
|response to monosaccharide|
|cell maturation|
|response to corticosteroid|
|mitochondrial outer membrane|
|cellular response to insulin stimulus|
|response to carbohydrate|
|negative regulation of canonical Wnt signaling pathway|
|regulation of reactive oxygen species metabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to hypoxia|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|response to starvation|
|response to ketone|
|cellular response to decreased oxygen levels|
|regulation of neuron apoptotic process|
|gonad development|
|negative regulation of Wnt signaling pathway|
|cellular response to oxygen levels|
|development of primary sexual characteristics|
|regulation of myeloid cell differentiation|
|negative regulation of neuron differentiation|
|response to insulin|
|response to alcohol|
|regulation of muscle system process|
|cellular response to tumor necrosis factor|
|developmental maturation|
|cellular response to oxidative stress|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|germ cell development|
|negative regulation of cell migration|
|response to tumor necrosis factor|
|sex differentiation|
|cellular response to peptide hormone stimulus|
|negative regulation of cell motility|
|rhythmic process|
|aging|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|negative regulation of neurogenesis|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|cellular response to peptide|
|response to steroid hormone|
|regulation of autophagy|
|transcription factor binding|
|negative regulation of cell development|
|response to hypoxia|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|mitochondrial matrix|
|response to oxygen levels|
|response to oxidative stress|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of cellular amide metabolic process|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|protein kinase binding|
|response to peptide|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|response to growth factor|
|cellular response to organic cyclic compound|
|regulation of system process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|gamete generation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|cellular response to DNA damage stimulus|
|head development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of catabolic process|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|chemical homeostasis|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.74|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXO3 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>