======= FSCN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FSCN1
  * **<color #00a2e8>Official Name</color>**: fascin actin-bundling protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6624|6624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16658|Q16658]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FSCN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FSCN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602689|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:9362073, ECO:0000269|PubMed:9571235}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fascin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microspike assembly|
|microspike|
|regulation of microvillus assembly|
|parallel actin filament bundle assembly|
|positive regulation of extracellular matrix disassembly|
|invadopodium|
|cell projection membrane|
|positive regulation of podosome assembly|
|regulation of microvillus organization|
|regulation of podosome assembly|
|regulation of extracellular matrix disassembly|
|establishment of apical/basal cell polarity|
|positive regulation of lamellipodium assembly|
|positive regulation of extracellular matrix organization|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|positive regulation of lamellipodium organization|
|podosome|
|regulation of lamellipodium assembly|
|positive regulation of filopodium assembly|
|regulation of extracellular matrix organization|
|regulation of lamellipodium organization|
|regulation of filopodium assembly|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|drug binding|
|actin filament bundle assembly|
|microvillus|
|actin filament bundle organization|
|stress fiber|
|filopodium|
|positive regulation of organelle assembly|
|protein binding, bridging|
|ruffle|
|positive regulation of plasma membrane bounded cell projection assembly|
|cell-cell junction assembly|
|establishment of cell polarity|
|growth cone|
|cell-cell junction organization|
|cell junction assembly|
|cell-cell junction|
|lamellipodium|
|establishment or maintenance of cell polarity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|actin filament binding|
|cell junction organization|
|actin cytoskeleton|
|regulation of organelle assembly|
|actin filament organization|
|positive regulation of protein complex assembly|
|actin binding|
|cadherin binding|
|regulation of actin cytoskeleton organization|
|cytoskeleton|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|actin filament-based process|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular component biogenesis|
|cell migration|
|cellular response to cytokine stimulus|
|localization of cell|
|cell motility|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|RNA binding|
|movement of cell or subcellular component|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.81|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.12|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.18|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.69|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FSCN1 Expression in NALM6 Cells: -0.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>