======= FSCN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FSCN2
  * **<color #00a2e8>Official Name</color>**: fascin actin-bundling protein 2, retinal
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25794|25794]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14926|O14926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FSCN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FSCN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fascin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stereocilium|
|eye photoreceptor cell development|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|photoreceptor cell differentiation|
|actin filament bundle assembly|
|actin filament bundle organization|
|protein binding, bridging|
|eye morphogenesis|
|establishment or maintenance of cell polarity|
|actin filament binding|
|actin cytoskeleton|
|visual perception|
|sensory perception of light stimulus|
|actin filament organization|
|sensory organ morphogenesis|
|actin binding|
|eye development|
|visual system development|
|sensory system development|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|sensory organ development|
|actin filament-based process|
|neuron development|
|animal organ morphogenesis|
|cell migration|
|sensory perception|
|neuron differentiation|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FSCN2 Expression in NALM6 Cells: -1.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>