======= FTH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FTH1
  * **<color #00a2e8>Official Name</color>**: ferritin heavy chain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2495|2495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02794|P02794]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FTH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FTH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferritin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular ferritin complex|
|intracellular sequestering of iron ion|
|sequestering of iron ion|
|autolysosome|
|ferroxidase activity|
|ferric iron binding|
|sequestering of metal ion|
|ferrous iron binding|
|negative regulation of fibroblast proliferation|
|tertiary granule lumen|
|cellular iron ion homeostasis|
|iron ion transport|
|iron ion homeostasis|
|regulation of fibroblast proliferation|
|maintenance of location in cell|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|ficolin-1-rich granule lumen|
|transition metal ion homeostasis|
|iron ion binding|
|maintenance of location|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cellular metal ion homeostasis|
|myeloid leukocyte activation|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|negative regulation of cell population proliferation|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|cation transport|
|cellular homeostasis|
|leukocyte activation|
|oxidation-reduction process|
|secretion by cell|
|export from cell|
|identical protein binding|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|ion transport|
|regulation of cell population proliferation|
|homeostatic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3560
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FTH1 Expression in NALM6 Cells: 7.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>