======= G6PD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: G6PD
  * **<color #00a2e8>Official Name</color>**: glucose-6-phosphate dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2539|2539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11413|P11413]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=G6PD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20G6PD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/305900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. {ECO:0000269|PubMed:15858258, ECO:0000269|PubMed:24769394}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G6PD N|
|G6PD C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucose-6-phosphate dehydrogenase activity|
|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|regulation of protein glutathionylation|
|negative regulation of protein glutathionylation|
|pentose-phosphate shunt, oxidative branch|
|pentose biosynthetic process|
|response to iron(III) ion|
|negative regulation of cell growth involved in cardiac muscle cell development|
|glucose binding|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|pentose-phosphate shunt|
|erythrocyte maturation|
|pentose metabolic process|
|NADPH regeneration|
|negative regulation of cardiac muscle cell differentiation|
|regulation of cell growth involved in cardiac muscle cell development|
|negative regulation of cardiocyte differentiation|
|response to food|
|negative regulation of heart growth|
|glucose 6-phosphate metabolic process|
|negative regulation of cardiac muscle tissue growth|
|negative regulation of cardiac muscle hypertrophy|
|NADP metabolic process|
|negative regulation of muscle hypertrophy|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|erythrocyte development|
|response to iron ion|
|regulation of cardiac muscle cell differentiation|
|NADP binding|
|negative regulation of striated muscle cell differentiation|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|substantia nigra development|
|sterol biosynthetic process|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|cytoplasmic side of plasma membrane|
|monosaccharide biosynthetic process|
|negative regulation of reactive oxygen species metabolic process|
|glutathione metabolic process|
|negative regulation of muscle cell differentiation|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|myeloid cell development|
|neural nucleus development|
|regulation of heart growth|
|positive regulation of calcium ion transmembrane transport|
|regulation of cardiac muscle tissue development|
|erythrocyte differentiation|
|midbrain development|
|regulation of muscle adaptation|
|erythrocyte homeostasis|
|regulation of organ growth|
|regulation of striated muscle cell differentiation|
|negative regulation of developmental growth|
|myeloid cell homeostasis|
|alcohol biosynthetic process|
|glucose metabolic process|
|cholesterol metabolic process|
|positive regulation of calcium ion transport|
|carbohydrate biosynthetic process|
|steroid biosynthetic process|
|response to ethanol|
|secondary alcohol metabolic process|
|regulation of striated muscle tissue development|
|sterol metabolic process|
|regulation of muscle tissue development|
|anatomical structure maturation|
|regulation of muscle organ development|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|regulation of muscle cell differentiation|
|positive regulation of ion transmembrane transport|
|hexose metabolic process|
|cell maturation|
|ribose phosphate biosynthetic process|
|regulation of reactive oxygen species metabolic process|
|negative regulation of cell growth|
|organic hydroxy compound biosynthetic process|
|cellular modified amino acid metabolic process|
|monosaccharide metabolic process|
|homeostasis of number of cells|
|positive regulation of transmembrane transport|
|regulation of neuron apoptotic process|
|myeloid cell differentiation|
|response to alcohol|
|regulation of muscle system process|
|developmental maturation|
|cellular response to oxidative stress|
|negative regulation of growth|
|regulation of calcium ion transport|
|steroid metabolic process|
|positive regulation of ion transport|
|response to antibiotic|
|regulation of neuron death|
|alcohol metabolic process|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|negative regulation of cell development|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|response to metal ion|
|regulation of metal ion transport|
|response to oxidative stress|
|regulation of cell growth|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|response to nutrient levels|
|response to toxic substance|
|peptide metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|organophosphate biosynthetic process|
|hemopoiesis|
|regulation of transmembrane transport|
|lipid biosynthetic process|
|regulation of system process|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|immune system development|
|regulation of growth|
|regulation of ion transport|
|negative regulation of cell differentiation|
|brain development|
|head development|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|regulation of cell development|
|negative regulation of developmental process|
|oxidation-reduction process|
|central nervous system development|
|positive regulation of transport|
|response to drug|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|homeostatic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.52|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.37|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.08|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.82|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.7|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.72|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.77|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.82|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.84|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.92|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.92|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.93|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.04|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.08|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.14|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.14|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.21|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.38|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.46|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.48|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.55|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.59|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gatc|GATC]]|0.48|
|[[:human genes:t:trmt61a|TRMT61A]]|0.462|
|[[:human genes:f:fh|FH]]|0.461|
|[[:human genes:p:pmvk|PMVK]]|0.459|
|[[:human genes:p:ppcdc|PPCDC]]|0.456|
|[[:human genes:t:tars2|TARS2]]|0.449|
|[[:human genes:m:mrpl21|MRPL21]]|0.449|
|[[:human genes:d:ddx39a|DDX39A]]|0.443|
|[[:human genes:d:dnlz|DNLZ]]|0.439|
|[[:human genes:p:pmm2|PMM2]]|0.436|
|[[:human genes:n:n6amt1|N6AMT1]]|0.433|
|[[:human genes:p:pars2|PARS2]]|0.43|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.428|
|[[:human genes:p:pgm3|PGM3]]|0.427|
|[[:human genes:e:elp6|ELP6]]|0.422|
|[[:human genes:t:thg1l|THG1L]]|0.418|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.413|
|[[:human genes:t:tmem242|TMEM242]]|0.411|
|[[:human genes:m:mrps5|MRPS5]]|0.407|
|[[:human genes:s:slc25a26|SLC25A26]]|0.406|
|[[:human genes:r:rbfa|RBFA]]|0.4|
|[[:human genes:t:tamm41|TAMM41]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='G6PD Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>