======= GADD45A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GADD45A
  * **<color #00a2e8>Official Name</color>**: growth arrest and DNA damage inducible alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1647|1647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24522|P24522]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GADD45A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GADD45A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126335|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L7Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of MAPKKK activity|
|mitotic cell cycle arrest|
|positive regulation of p38MAPK cascade|
|RNA polymerase II core promoter sequence-specific DNA binding|
|regulation of p38MAPK cascade|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|cellular response to ionizing radiation|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|cellular response to mechanical stimulus|
|positive regulation of cell cycle arrest|
|centrosome cycle|
|microtubule organizing center organization|
|kinase binding|
|mitotic DNA damage checkpoint|
|positive regulation of reactive oxygen species metabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|protein N-terminus binding|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|positive regulation of JNK cascade|
|DNA integrity checkpoint|
|cell cycle arrest|
|response to ionizing radiation|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cellular response to radiation|
|regulation of reactive oxygen species metabolic process|
|regulation of JNK cascade|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|response to mechanical stimulus|
|negative regulation of protein kinase activity|
|negative regulation of cell cycle phase transition|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of kinase activity|
|positive regulation of MAP kinase activity|
|negative regulation of transferase activity|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of cell cycle|
|nuclear speck|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|microtubule-based process|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein homodimerization activity|
|apoptotic process|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of protein modification process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.08|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.9|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.87|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.8|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GADD45A Expression in NALM6 Cells: 4.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>