======= GAS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAS2
  * **<color #00a2e8>Official Name</color>**: growth arrest specific 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2620|2620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43903|O43903]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602835|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|GAS2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|initiation of primordial ovarian follicle growth|
|antral ovarian follicle growth|
|ovulation|
|basement membrane organization|
|ovulation cycle process|
|ovarian follicle development|
|ovulation cycle|
|actin filament|
|female gonad development|
|development of primary female sexual characteristics|
|regulation of Notch signaling pathway|
|female sex differentiation|
|female gamete generation|
|cell cycle arrest|
|regulation of cell shape|
|gonad development|
|development of primary sexual characteristics|
|microtubule binding|
|sex differentiation|
|rhythmic process|
|extracellular matrix organization|
|extracellular structure organization|
|developmental growth|
|growth|
|reproductive structure development|
|reproductive system development|
|regulation of cell morphogenesis|
|negative regulation of cell cycle|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|apoptotic process|
|multi-organism reproductive process|
|cell cycle process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of cell cycle|
|cell cycle|
|reproductive process|
|reproduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAS2 Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>