======= GATA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GATA1
  * **<color #00a2e8>Official Name</color>**: GATA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2623|2623]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15976|P15976]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GATA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/305371|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). {ECO:0000269|PubMed:22235304, ECO:0000269|PubMed:24245781}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GATA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basophil differentiation|
|regulation of primitive erythrocyte differentiation|
|eosinophil fate commitment|
|eosinophil differentiation|
|dsDNA loop formation|
|gene looping|
|transcriptional activation by promoter-enhancer looping|
|regulation of definitive erythrocyte differentiation|
|positive regulation of osteoblast proliferation|
|C2H2 zinc finger domain binding|
|cellular response to thyroid hormone stimulus|
|granulocyte differentiation|
|platelet formation|
|negative regulation of bone mineralization|
|platelet morphogenesis|
|embryonic hemopoiesis|
|megakaryocyte differentiation|
|negative regulation of transcription regulatory region DNA binding|
|regulation of osteoblast proliferation|
|response to thyroid hormone|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|positive regulation of erythrocyte differentiation|
|homeostasis of number of cells within a tissue|
|dendritic cell differentiation|
|erythrocyte development|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of glycoprotein biosynthetic process|
|protein-DNA complex|
|platelet aggregation|
|regulation of glycoprotein metabolic process|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of erythrocyte differentiation|
|regulation of transcription regulatory region DNA binding|
|regulation of megakaryocyte differentiation|
|negative regulation of DNA binding|
|transcriptional repressor complex|
|myeloid cell development|
|homotypic cell-cell adhesion|
|RNA polymerase II transcription factor binding|
|p53 binding|
|chromatin DNA binding|
|regulation of hematopoietic stem cell differentiation|
|negative regulation of ossification|
|regulation of bone mineralization|
|transcription regulatory region sequence-specific DNA binding|
|erythrocyte differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of extrinsic apoptotic signaling pathway|
|myeloid cell homeostasis|
|myeloid leukocyte differentiation|
|regulation of stem cell differentiation|
|regulation of DNA binding|
|regulation of embryonic development|
|male gonad development|
|development of primary male sexual characteristics|
|platelet activation|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|negative regulation of binding|
|positive regulation of hemopoiesis|
|tissue homeostasis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of ossification|
|homeostasis of number of cells|
|transcription factor complex|
|gonad development|
|development of primary sexual characteristics|
|myeloid cell differentiation|
|negative regulation of apoptotic signaling pathway|
|regulation of myeloid cell differentiation|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|sex differentiation|
|blood coagulation|
|coagulation|
|hemostasis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|multicellular organismal homeostasis|
|leukocyte differentiation|
|anatomical structure homeostasis|
|regulation of binding|
|in utero embryonic development|
|regulation of apoptotic signaling pathway|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|wound healing|
|transcription by RNA polymerase II|
|regulation of body fluid levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell-cell adhesion|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|chromatin organization|
|cell morphogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chromosome organization|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16102
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GATA1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>