======= GATA3 ======= == Gene Information == * **Official Symbol**: GATA3 * **Official Name**: GATA binding protein 3 * **Aliases and Previous Symbols**: N/A * **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2625|2625]] * **UniProt**: [[https://www.uniprot.org/uniprot/P23771|P23771]] * **Interactions**: [[https://thebiogrid.org/search.php?search=GATA3&organism=9606|BioGRID]] * **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA3|Open PubMed]] * **OMIM**: [[https://omim.org/entry/131320|Open OMIM]] == Function Summary == * **Entrez Summary**: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]. * **UniProt Summary**: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}. |GATA| |parathyroid hormone secretion| |negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation| |regulation of cell proliferation involved in mesonephros development| |pro-T cell differentiation| |type IV hypersensitivity| |negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation| |negative regulation of cell proliferation involved in mesonephros development| |negative regulation of epithelial tube formation| |regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation| |regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation| |hypersensitivity| |canonical Wnt signaling pathway involved in metanephric kidney development| |regulation of cellular response to X-ray| |Wnt signaling pathway involved in kidney development| |cell-cell signaling involved in metanephros development| |cell-cell signaling involved in kidney development| |T-helper 2 cell differentiation| |positive regulation of thyroid hormone generation| |ureteric bud formation| |negative regulation of DNA demethylation| |mast cell differentiation| |negative regulation of mesonephros development| |positive regulation of histone H3-K14 acetylation| |regulation of ureteric bud formation| |ureter maturation| |positive regulation of epithelial tube formation| |positive regulation of ureteric bud formation| |negative regulation of mammary gland epithelial cell proliferation| |regulation of thyroid hormone generation| |interleukin-2 receptor binding| |negative regulation of cell proliferation involved in kidney development| |nephric duct formation| |interleukin-4 secretion| |positive regulation of interleukin-13 secretion| |positive regulation of interleukin-5 secretion| |regulation of histone H3-K14 acetylation| |positive regulation of T-helper 2 cell cytokine production| |interleukin-4 production| |mesonephric tubule formation| |norepinephrine biosynthetic process| |regulation of DNA demethylation| |ureter morphogenesis| |parathyroid gland development| |type 2 immune response| |acute inflammatory response to antigenic stimulus| |positive regulation of histone H3-K9 acetylation| |regulation of interleukin-5 secretion| |interferon-gamma secretion| |regulation of interleukin-13 secretion| |regulation of T-helper 2 cell cytokine production| |cellular response to interferon-alpha| |endocrine hormone secretion| |regulation of histone H3-K27 methylation| |nephric duct morphogenesis| |lymphoid progenitor cell differentiation| |norepinephrine metabolic process| |regulation of nephron tubule epithelial cell differentiation| |positive regulation of interleukin-5 production| |otic vesicle development| |regulation of histone H3-K9 acetylation| |regulation of cell proliferation involved in kidney development| |mesenchymal to epithelial transition| |ureter development| |positive regulation of interleukin-13 production| |positive regulation of hormone metabolic process| |nephric duct development| |negative regulation of fibroblast growth factor receptor signaling pathway| |positive regulation of type 2 immune response| |negative regulation of morphogenesis of an epithelium| |negative regulation of kidney development| |HMG box domain binding| |nephron tubule formation| |regulation of mammary gland epithelial cell proliferation| |interferon-gamma production| |positive regulation of T cell cytokine production| |regulation of epithelial tube formation| |thymic T cell selection| |catechol-containing compound biosynthetic process| |regulation of epithelial cell differentiation involved in kidney development| |catecholamine biosynthetic process| |cardiac right ventricle morphogenesis| |embryonic hemopoiesis| |regulation of establishment of cell polarity| |response to interferon-alpha| |animal organ maturation| |sympathetic nervous system development| |positive regulation of mesonephros development| |regulation of interleukin-13 production| |uterus development| |regulation of interleukin-5 production| |negative regulation of interleukin-2 production| |positive regulation of interleukin-4 production| |inflammatory response to antigenic stimulus| |enhancer sequence-specific DNA binding| |regulation of establishment or maintenance of cell polarity| |regulation of mesonephros development| |positive regulation of transcription regulatory region DNA binding| |negative regulation of embryonic development| |pharyngeal system development| |T-helper cell differentiation| |regulation of interleukin-4 production| |regulation of histone H3-K4 methylation| |CD4-positive, alpha-beta T cell differentiation involved in immune response| |alpha-beta T cell differentiation involved in immune response| |alpha-beta T cell activation involved in immune response| |aortic valve morphogenesis| |TOR signaling| |cellular response to interleukin-4| |regulation of fibroblast growth factor receptor signaling pathway| |regulation of type 2 immune response| |positive regulation of histone acetylation| |negative regulation of endothelial cell apoptotic process| |proximal promoter sequence-specific DNA binding| |response to interleukin-4| |regulation of T cell cytokine production| |aortic valve development| |T cell differentiation involved in immune response| |phosphatidylinositol 3-kinase signaling| |positive regulation of peptidyl-lysine acetylation| |negative regulation of interferon-gamma production| |phenol-containing compound biosynthetic process| |negative regulation of animal organ morphogenesis| |positive regulation of morphogenesis of an epithelium| |CD4-positive, alpha-beta T cell differentiation| |positive regulation of embryonic development| |semi-lunar valve development| |regulation of hormone metabolic process| |CD4-positive, alpha-beta T cell activation| |T cell selection| |cell fate determination| |positive regulation of kidney development| |positive regulation of protein acetylation| |negative regulation of epithelial cell apoptotic process| |T cell mediated immunity| |catecholamine metabolic process| |catechol-containing compound metabolic process| |autonomic nervous system development| |thymus development| |negative regulation of fat cell differentiation| |regulation of CD4-positive, alpha-beta T cell differentiation| |T cell differentiation in thymus| |positive regulation of T cell mediated immunity| |endocrine process| |cytokine secretion| |E-box binding| |regulation of endothelial cell apoptotic process| |alpha-beta T cell differentiation| |cochlea development| |heart valve morphogenesis| |regulation of transcription regulatory region DNA binding| |ureteric bud morphogenesis| |mesonephric tubule morphogenesis| |regulation of interleukin-2 production| |positive regulation of cytokine production involved in immune response| |regulation of kidney development| |positive regulation of DNA binding| |regulation of histone acetylation| |response to gamma radiation| |regulation of CD4-positive, alpha-beta T cell activation| |heart valve development| |alpha-beta T cell activation| |regulation of alpha-beta T cell differentiation| |regulation of peptidyl-lysine acetylation| |T cell activation involved in immune response| |nephron tubule morphogenesis| |regulation of histone methylation| |nephron epithelium morphogenesis| |lymphocyte migration| |nephron morphogenesis| |renal tubule morphogenesis| |acute inflammatory response| |regulation of T cell mediated immunity| |regulation of protein acetylation| |phosphatidylinositol-mediated signaling| |regulation of hematopoietic stem cell differentiation| |hormone secretion| |ventricular septum development| |cardiac ventricle morphogenesis| |inositol lipid-mediated signaling| |response to estrogen| |transcription regulatory region sequence-specific DNA binding| |nephron tubule development| |lens development in camera-type eye| |regulation of epithelial cell apoptotic process| |renal tubule development| |erythrocyte differentiation| |hormone transport| |positive regulation of animal organ morphogenesis| |positive regulation of T cell differentiation| |phenol-containing compound metabolic process| |metanephros development| |regulation of cytokine production involved in immune response| |kidney morphogenesis| |ureteric bud development| |regulation of hematopoietic progenitor cell differentiation| |mesonephric tubule development| |hematopoietic progenitor cell differentiation| |mesonephric epithelium development| |post-embryonic development| |erythrocyte homeostasis| |canonical Wnt signaling pathway| |mesonephros development| |positive regulation of histone modification| |regulation of alpha-beta T cell activation| |positive regulation of lymphocyte differentiation| |nephron epithelium development| |positive regulation of production of molecular mediator of immune response| |inner ear morphogenesis| |positive regulation of endothelial cell migration| |regulation of interferon-gamma production| |positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains| |positive regulation of chromatin organization| |cellular response to BMP stimulus| |regulation of cytokine biosynthetic process| |response to BMP| |positive regulation of lymphocyte mediated immunity| |positive regulation of adaptive immune response| |myeloid cell homeostasis| |cardiac septum development| |lymphocyte activation involved in immune response| |myeloid leukocyte differentiation| |regulation of stem cell differentiation| |ear morphogenesis| |neuron migration| |endocrine system development| |negative regulation of DNA metabolic process| |regulation of fat cell differentiation| |embryonic epithelial tube formation| |negative regulation of epithelial cell proliferation| |nephron development| |regulation of DNA binding| |cardiac chamber morphogenesis| |response to ethanol| |cardiac ventricle development| |kidney epithelium development| |regulation of embryonic development| |epithelial tube formation| |positive regulation of leukocyte mediated immunity| |male gonad development| |development of primary male sexual characteristics| |anatomical structure maturation| |T cell differentiation| |negative regulation of inflammatory response| |regulation of T cell differentiation| |positive regulation of cytokine secretion| |regulation of production of molecular mediator of immune response| |positive regulation of epithelial cell migration| |regulation of epithelial cell differentiation| |regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains| |morphogenesis of embryonic epithelium| |regulation of histone modification| |negative regulation of cellular response to growth factor stimulus| |tube formation| |positive regulation of leukocyte differentiation| |response to ionizing radiation| |cytokine production| |regulation of lymphocyte mediated immunity| |male sex differentiation| |regulation of endothelial cell migration| |cell maturation| |protein secretion| |protein dimerization activity| |establishment of protein localization to extracellular region| |regulation of adaptive immune response| |chromatin remodeling| |positive regulation of protein kinase B signaling| |protein localization to extracellular region| |regulation of lymphocyte differentiation| |signal release| |cardiac chamber development| |peptide secretion| |positive regulation of chromosome organization| |T cell receptor signaling pathway| |positive regulation of binding| |regulation of morphogenesis of an epithelium| |organic hydroxy compound biosynthetic process| |positive regulation of hemopoiesis| |regulation of chromatin organization| |inner ear development| |homeostasis of number of cells| |positive regulation of T cell activation| |regulation of cytokine secretion| |regulation of leukocyte mediated immunity| |regulation of neuron apoptotic process| |negative regulation of defense response| |gonad development| |positive regulation of leukocyte cell-cell adhesion| |development of primary sexual characteristics| |transcription regulatory region DNA binding| |positive regulation of immune effector process| |myeloid cell differentiation| |regulation of protein kinase B signaling| |regulation of epithelial cell migration| |ear development| |response to alcohol| |T cell activation| |nuclear chromatin| |lymphocyte differentiation| |developmental maturation| |cellular response to tumor necrosis factor| |DNA-binding transcription repressor activity, RNA polymerase II-specific| |cell fate commitment| |heart morphogenesis| |positive regulation of cell-cell adhesion| |sensory organ morphogenesis| |regulation of animal organ morphogenesis| |axon guidance| |neuron projection guidance| |response to tumor necrosis factor| |sex differentiation| |lymphocyte mediated immunity| |kidney development| |positive regulation of protein secretion| |regulation of cellular response to growth factor stimulus| |regulation of leukocyte differentiation| |negative regulation of cell motility| |negative regulation of cytokine production| |adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains| |response to virus| |protein deubiquitination| |renal system development| |transcription coactivator activity| |embryonic organ morphogenesis| |positive regulation of peptide secretion| |blood coagulation| |coagulation| |antigen receptor-mediated signaling pathway| |regulation of leukocyte cell-cell adhesion| |protein modification by small protein removal| |hemostasis| |response to antibiotic| |epithelial tube morphogenesis| |negative regulation of cellular component movement| |regulation of neuron death| |camera-type eye development| |regulation of T cell activation| |urogenital system development| |negative regulation of locomotion| |leukocyte differentiation| |transcription factor binding| |regulation of epithelial cell proliferation| |regulation of inflammatory response| |humoral immune response| |regulation of chromosome organization| |regulation of DNA metabolic process| |cell-cell signaling by wnt| |Wnt signaling pathway| |eye development| |positive regulation of lymphocyte activation| |visual system development| |negative regulation of response to external stimulus| |sensory system development| |axonogenesis| |in utero embryonic development| |regulation of binding| |leukocyte migration| |lymphocyte activation| |developmental growth| |growth| |regulation of cell-cell adhesion| |positive regulation of secretion by cell| |positive regulation of cell adhesion| |positive regulation of leukocyte activation| |axon development| |gland development| |positive regulation of cell activation| |reproductive structure development| |positive regulation of protein transport| |cell surface receptor signaling pathway involved in cell-cell signaling| |reproductive system development| |morphogenesis of an epithelium| |cell morphogenesis involved in neuron differentiation| |embryonic organ development| |positive regulation of secretion| |response to radiation| |DNA-binding transcription activator activity, RNA polymerase II-specific| |immune response-activating cell surface receptor signaling pathway| |positive regulation of cytokine production| |regulation of hemopoiesis| |organic hydroxy compound metabolic process| |positive regulation of establishment of protein localization| |regulation of protein secretion| |regulation of immune effector process| |wound healing| |neuron projection morphogenesis| |transcription by RNA polymerase II| |immune response-regulating cell surface receptor signaling pathway| |plasma membrane bounded cell projection morphogenesis| |cell projection morphogenesis| |regulation of peptide secretion| |regulation of body fluid levels| |regulation of neuron projection development| |inflammatory response| |cellular response to growth factor stimulus| |positive regulation of cell migration| |RNA polymerase II proximal promoter sequence-specific DNA binding| |response to toxic substance| |cell part morphogenesis| |regulation of lymphocyte activation| |positive regulation of cell motility| |heart development| |response to growth factor| |regulation of hormone levels| |positive regulation of cellular component movement| |sensory organ development| |chemotaxis| |positive regulation of locomotion| |taxis| |cell morphogenesis involved in differentiation| |hemopoiesis| |immune response-activating signal transduction| |tissue morphogenesis| |embryonic morphogenesis| |response to wounding| |negative regulation of cell cycle| |immune response-regulating signaling pathway| |regulation of leukocyte activation| |hematopoietic or lymphoid organ development| |adaptive immune response| |positive regulation of organelle organization| |leukocyte activation involved in immune response| |cell activation involved in immune response| |activation of immune response| |chordate embryonic development| |transcription, DNA-templated| |regulation of cell activation| |nucleic acid-templated transcription| |immune system development| |embryo development ending in birth or egg hatching| |RNA biosynthetic process| |tube morphogenesis| |regulation of neuron differentiation| |neuron projection development| |developmental process involved in reproduction| |cytokine-mediated signaling pathway| |DNA-binding transcription factor activity| |negative regulation of cell population proliferation| |regulation of cell adhesion| |epithelial cell differentiation| |regulation of plasma membrane bounded cell projection organization| |regulation of cytokine production| |chromatin organization| |regulation of protein transport| |regulation of cell projection organization| |negative regulation of cell differentiation| |cell morphogenesis| |regulation of peptide transport| |regulation of establishment of protein localization| |regulation of secretion by cell| |regulation of defense response| |leukocyte mediated immunity| |innate immune response| |regulation of secretion| |neuron development| |regulation of neurogenesis| |cellular component morphogenesis| |zinc ion binding| |tube development| |regulation of cell migration| |negative regulation of transcription by RNA polymerase II| |positive regulation of immune response| |circulatory system development| |negative regulation of apoptotic process| |anatomical structure formation involved in morphogenesis| |negative regulation of programmed cell death| |regulation of cell motility| |regulation of nervous system development| |leukocyte activation| |regulation of cell development| |negative regulation of developmental process| |defense response to other organism| |animal organ morphogenesis| |cell migration| |positive regulation of cell differentiation| |embryo development| |regulation of locomotion| |protein modification by small protein conjugation or removal| |positive regulation of transport| |negative regulation of cell death| |regulation of cellular component movement| |secretion by cell| |cellular response to cytokine stimulus| |neuron differentiation| |response to drug| |positive regulation of intracellular signal transduction| |regulation of protein localization| |export from cell| |regulation of anatomical structure morphogenesis| |chromosome organization| |cell activation| |localization of cell| |cell motility| |immune effector process| |regulation of response to external stimulus| |nucleobase-containing compound biosynthetic process| |response to cytokine| |epithelium development| |cell-cell signaling| |secretion| |plasma membrane bounded cell projection organization| |positive regulation of immune system process| |regulation of immune response| |cell projection organization| |response to abiotic stimulus| |heterocycle biosynthetic process| |aromatic compound biosynthetic process| |regulation of cell cycle| |negative regulation of transcription, DNA-templated| |negative regulation of multicellular organismal process| |positive regulation of cellular component organization| |positive regulation of transcription by RNA polymerase II| |cellular response to endogenous stimulus| |positive regulation of protein modification process| |negative regulation of nucleic acid-templated transcription| |negative regulation of RNA biosynthetic process| |negative regulation of signal transduction| |proteolysis| |regulation of organelle organization| |response to other organism| |organic cyclic compound biosynthetic process| |response to external biotic stimulus| |locomotion| |response to biotic stimulus| |negative regulation of RNA metabolic process| |defense response| |negative regulation of cell communication| |negative regulation of signaling| |positive regulation of developmental process| |negative regulation of cellular macromolecule biosynthetic process| |organonitrogen compound biosynthetic process| |reproductive process| |reproduction| |negative regulation of nucleobase-containing compound metabolic process| |DNA binding| |negative regulation of macromolecule biosynthetic process| |response to endogenous stimulus| |regulation of response to stress| |protein transport| |negative regulation of cellular biosynthetic process| |generation of neurons| |peptide transport| |positive regulation of transcription, DNA-templated| |regulation of apoptotic process| |negative regulation of biosynthetic process| |movement of cell or subcellular component| |response to oxygen-containing compound| |DNA-binding transcription factor activity, RNA polymerase II-specific| |regulation of programmed cell death| |amide transport| |positive regulation of cellular protein metabolic process| |establishment of protein localization| |regulation of cell population proliferation| |negative regulation of response to stimulus| |neurogenesis| |cellular nitrogen compound biosynthetic process| |positive regulation of nucleic acid-templated transcription| |positive regulation of RNA biosynthetic process| |homeostatic process| |cell development| |positive regulation of signal transduction| |regulation of immune system process| |RNA metabolic process| |regulation of cell death| |intracellular signal transduction| |positive regulation of protein metabolic process| |cellular macromolecule biosynthetic process| |negative regulation of gene expression| |positive regulation of RNA metabolic process| |positive regulation of multicellular organismal process| |tissue development| |macromolecule biosynthetic process| |positive regulation of molecular function| |regulation of cell differentiation| |positive regulation of cell communication| |positive regulation of signaling| |regulation of intracellular signal transduction| |nitrogen compound transport| |regulation of protein modification process| |regulation of transport| |immune response| |positive regulation of nucleobase-containing compound metabolic process| |positive regulation of macromolecule biosynthetic process| |system process| |positive regulation of cellular biosynthetic process| |positive regulation of gene expression| |gene expression| |positive regulation of biosynthetic process| \\ === CRISPR Data === ^Screen^Score^ |[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.79| |[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.81| |[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.91| |[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.97| |[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.98| |[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.07| |[[:results:exp59|UMK57 1μM R01 exp59]]|2.12| |[[:results:exp517|Quercetin 20μM R08 exp517]]|2.5| |[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.66| |[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.09| ^Gene^Correlation^ |[[:human genes:r:rrm1|RRM1]]|0.476| |[[:human genes:p:pan2|PAN2]]|0.466| |[[:human genes:h:h3f3a|H3F3A]]|0.452| |[[:human genes:c:cdk13|CDK13]]|0.443| |[[:human genes:c:copb1|COPB1]]|0.405| Global Fraction of Cell Lines Where Essential: 16/739 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|0/28| |blood|0/28| |bone|0/26| |breast|8/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|0/13| |fibroblast|0/1| |gastric|0/16| |kidney|0/21| |liver|0/20| |lung|0/75| |lymphocyte|0/16| |ovary|0/26| |pancreas|0/24| |peripheral nervous system|3/16| |plasma cell|0/15| |prostate|0/1| |skin|0/24| |soft tissue|0/9| |thyroid|0/2| |upper aerodigestive|0/22| |urinary tract|1/29| |uterus|0/5| == Essentiality in NALM6 == * **Essentiality Rank**: 1521 * **Expression level (log2 read counts)**: 3.86 {{:chemogenomics:nalm6 dist.png?nolink |}}