======= GATA3 =======
== Gene Information ==
* **Official Symbol**: GATA3
* **Official Name**: GATA binding protein 3
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2625|2625]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P23771|P23771]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=GATA3&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GATA3|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/131320|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
* **UniProt Summary**: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}.
|GATA|
|parathyroid hormone secretion|
|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|
|regulation of cell proliferation involved in mesonephros development|
|pro-T cell differentiation|
|type IV hypersensitivity|
|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|
|negative regulation of cell proliferation involved in mesonephros development|
|negative regulation of epithelial tube formation|
|regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|
|regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|
|hypersensitivity|
|canonical Wnt signaling pathway involved in metanephric kidney development|
|regulation of cellular response to X-ray|
|Wnt signaling pathway involved in kidney development|
|cell-cell signaling involved in metanephros development|
|cell-cell signaling involved in kidney development|
|T-helper 2 cell differentiation|
|positive regulation of thyroid hormone generation|
|ureteric bud formation|
|negative regulation of DNA demethylation|
|mast cell differentiation|
|negative regulation of mesonephros development|
|positive regulation of histone H3-K14 acetylation|
|regulation of ureteric bud formation|
|ureter maturation|
|positive regulation of epithelial tube formation|
|positive regulation of ureteric bud formation|
|negative regulation of mammary gland epithelial cell proliferation|
|regulation of thyroid hormone generation|
|interleukin-2 receptor binding|
|negative regulation of cell proliferation involved in kidney development|
|nephric duct formation|
|interleukin-4 secretion|
|positive regulation of interleukin-13 secretion|
|positive regulation of interleukin-5 secretion|
|regulation of histone H3-K14 acetylation|
|positive regulation of T-helper 2 cell cytokine production|
|interleukin-4 production|
|mesonephric tubule formation|
|norepinephrine biosynthetic process|
|regulation of DNA demethylation|
|ureter morphogenesis|
|parathyroid gland development|
|type 2 immune response|
|acute inflammatory response to antigenic stimulus|
|positive regulation of histone H3-K9 acetylation|
|regulation of interleukin-5 secretion|
|interferon-gamma secretion|
|regulation of interleukin-13 secretion|
|regulation of T-helper 2 cell cytokine production|
|cellular response to interferon-alpha|
|endocrine hormone secretion|
|regulation of histone H3-K27 methylation|
|nephric duct morphogenesis|
|lymphoid progenitor cell differentiation|
|norepinephrine metabolic process|
|regulation of nephron tubule epithelial cell differentiation|
|positive regulation of interleukin-5 production|
|otic vesicle development|
|regulation of histone H3-K9 acetylation|
|regulation of cell proliferation involved in kidney development|
|mesenchymal to epithelial transition|
|ureter development|
|positive regulation of interleukin-13 production|
|positive regulation of hormone metabolic process|
|nephric duct development|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of type 2 immune response|
|negative regulation of morphogenesis of an epithelium|
|negative regulation of kidney development|
|HMG box domain binding|
|nephron tubule formation|
|regulation of mammary gland epithelial cell proliferation|
|interferon-gamma production|
|positive regulation of T cell cytokine production|
|regulation of epithelial tube formation|
|thymic T cell selection|
|catechol-containing compound biosynthetic process|
|regulation of epithelial cell differentiation involved in kidney development|
|catecholamine biosynthetic process|
|cardiac right ventricle morphogenesis|
|embryonic hemopoiesis|
|regulation of establishment of cell polarity|
|response to interferon-alpha|
|animal organ maturation|
|sympathetic nervous system development|
|positive regulation of mesonephros development|
|regulation of interleukin-13 production|
|uterus development|
|regulation of interleukin-5 production|
|negative regulation of interleukin-2 production|
|positive regulation of interleukin-4 production|
|inflammatory response to antigenic stimulus|
|enhancer sequence-specific DNA binding|
|regulation of establishment or maintenance of cell polarity|
|regulation of mesonephros development|
|positive regulation of transcription regulatory region DNA binding|
|negative regulation of embryonic development|
|pharyngeal system development|
|T-helper cell differentiation|
|regulation of interleukin-4 production|
|regulation of histone H3-K4 methylation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|aortic valve morphogenesis|
|TOR signaling|
|cellular response to interleukin-4|
|regulation of fibroblast growth factor receptor signaling pathway|
|regulation of type 2 immune response|
|positive regulation of histone acetylation|
|negative regulation of endothelial cell apoptotic process|
|proximal promoter sequence-specific DNA binding|
|response to interleukin-4|
|regulation of T cell cytokine production|
|aortic valve development|
|T cell differentiation involved in immune response|
|phosphatidylinositol 3-kinase signaling|
|positive regulation of peptidyl-lysine acetylation|
|negative regulation of interferon-gamma production|
|phenol-containing compound biosynthetic process|
|negative regulation of animal organ morphogenesis|
|positive regulation of morphogenesis of an epithelium|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of embryonic development|
|semi-lunar valve development|
|regulation of hormone metabolic process|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|cell fate determination|
|positive regulation of kidney development|
|positive regulation of protein acetylation|
|negative regulation of epithelial cell apoptotic process|
|T cell mediated immunity|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|autonomic nervous system development|
|thymus development|
|negative regulation of fat cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|T cell differentiation in thymus|
|positive regulation of T cell mediated immunity|
|endocrine process|
|cytokine secretion|
|E-box binding|
|regulation of endothelial cell apoptotic process|
|alpha-beta T cell differentiation|
|cochlea development|
|heart valve morphogenesis|
|regulation of transcription regulatory region DNA binding|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of interleukin-2 production|
|positive regulation of cytokine production involved in immune response|
|regulation of kidney development|
|positive regulation of DNA binding|
|regulation of histone acetylation|
|response to gamma radiation|
|regulation of CD4-positive, alpha-beta T cell activation|
|heart valve development|
|alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|regulation of peptidyl-lysine acetylation|
|T cell activation involved in immune response|
|nephron tubule morphogenesis|
|regulation of histone methylation|
|nephron epithelium morphogenesis|
|lymphocyte migration|
|nephron morphogenesis|
|renal tubule morphogenesis|
|acute inflammatory response|
|regulation of T cell mediated immunity|
|regulation of protein acetylation|
|phosphatidylinositol-mediated signaling|
|regulation of hematopoietic stem cell differentiation|
|hormone secretion|
|ventricular septum development|
|cardiac ventricle morphogenesis|
|inositol lipid-mediated signaling|
|response to estrogen|
|transcription regulatory region sequence-specific DNA binding|
|nephron tubule development|
|lens development in camera-type eye|
|regulation of epithelial cell apoptotic process|
|renal tubule development|
|erythrocyte differentiation|
|hormone transport|
|positive regulation of animal organ morphogenesis|
|positive regulation of T cell differentiation|
|phenol-containing compound metabolic process|
|metanephros development|
|regulation of cytokine production involved in immune response|
|kidney morphogenesis|
|ureteric bud development|
|regulation of hematopoietic progenitor cell differentiation|
|mesonephric tubule development|
|hematopoietic progenitor cell differentiation|
|mesonephric epithelium development|
|post-embryonic development|
|erythrocyte homeostasis|
|canonical Wnt signaling pathway|
|mesonephros development|
|positive regulation of histone modification|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|nephron epithelium development|
|positive regulation of production of molecular mediator of immune response|
|inner ear morphogenesis|
|positive regulation of endothelial cell migration|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of chromatin organization|
|cellular response to BMP stimulus|
|regulation of cytokine biosynthetic process|
|response to BMP|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|myeloid cell homeostasis|
|cardiac septum development|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|regulation of stem cell differentiation|
|ear morphogenesis|
|neuron migration|
|endocrine system development|
|negative regulation of DNA metabolic process|
|regulation of fat cell differentiation|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|nephron development|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|response to ethanol|
|cardiac ventricle development|
|kidney epithelium development|
|regulation of embryonic development|
|epithelial tube formation|
|positive regulation of leukocyte mediated immunity|
|male gonad development|
|development of primary male sexual characteristics|
|anatomical structure maturation|
|T cell differentiation|
|negative regulation of inflammatory response|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|regulation of epithelial cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|morphogenesis of embryonic epithelium|
|regulation of histone modification|
|negative regulation of cellular response to growth factor stimulus|
|tube formation|
|positive regulation of leukocyte differentiation|
|response to ionizing radiation|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|male sex differentiation|
|regulation of endothelial cell migration|
|cell maturation|
|protein secretion|
|protein dimerization activity|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|chromatin remodeling|
|positive regulation of protein kinase B signaling|
|protein localization to extracellular region|
|regulation of lymphocyte differentiation|
|signal release|
|cardiac chamber development|
|peptide secretion|
|positive regulation of chromosome organization|
|T cell receptor signaling pathway|
|positive regulation of binding|
|regulation of morphogenesis of an epithelium|
|organic hydroxy compound biosynthetic process|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|inner ear development|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|regulation of neuron apoptotic process|
|negative regulation of defense response|
|gonad development|
|positive regulation of leukocyte cell-cell adhesion|
|development of primary sexual characteristics|
|transcription regulatory region DNA binding|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|ear development|
|response to alcohol|
|T cell activation|
|nuclear chromatin|
|lymphocyte differentiation|
|developmental maturation|
|cellular response to tumor necrosis factor|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|response to tumor necrosis factor|
|sex differentiation|
|lymphocyte mediated immunity|
|kidney development|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|protein deubiquitination|
|renal system development|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|protein modification by small protein removal|
|hemostasis|
|response to antibiotic|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|camera-type eye development|
|regulation of T cell activation|
|urogenital system development|
|negative regulation of locomotion|
|leukocyte differentiation|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|humoral immune response|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|positive regulation of lymphocyte activation|
|visual system development|
|negative regulation of response to external stimulus|
|sensory system development|
|axonogenesis|
|in utero embryonic development|
|regulation of binding|
|leukocyte migration|
|lymphocyte activation|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|gland development|
|positive regulation of cell activation|
|reproductive structure development|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|positive regulation of secretion|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|wound healing|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of neuron projection development|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|sensory organ development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|immune response-activating signal transduction|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|chordate embryonic development|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|chromatin organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.79|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.81|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.91|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.97|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.98|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.07|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.5|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.66|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.09|
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.476|
|[[:human genes:p:pan2|PAN2]]|0.466|
|[[:human genes:h:h3f3a|H3F3A]]|0.452|
|[[:human genes:c:cdk13|CDK13]]|0.443|
|[[:human genes:c:copb1|COPB1]]|0.405|
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|8/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 1521
* **Expression level (log2 read counts)**: 3.86
{{:chemogenomics:nalm6 dist.png?nolink |}}