======= GDI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDI2
  * **<color #00a2e8>Official Name</color>**: GDP dissociation inhibitor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2665|2665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50395|P50395]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rab GDP-dissociation inhibitor activity|
|azurophil granule lumen|
|secretory granule lumen|
|vesicle|
|Rab GTPase binding|
|synapse|
|GTPase activator activity|
|small GTPase mediated signal transduction|
|regulation of small GTPase mediated signal transduction|
|positive regulation of GTPase activity|
|focal adhesion|
|regulation of GTPase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|exocytosis|
|leukocyte activation|
|Golgi apparatus|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.13|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.65|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.38|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.79|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.99|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.99|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc39a9|SLC39A9]]|0.452|
|[[:human genes:s:sh3gl1|SH3GL1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6884
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDI2 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>