======= GEM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GEM
  * **<color #00a2e8>Official Name</color>**: GTP binding protein overexpressed in skeletal muscle
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2669|2669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55040|P55040]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GEM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GEM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600164|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Miro|
|FeoB N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of high voltage-gated calcium channel activity|
|negative regulation of voltage-gated calcium channel activity|
|regulation of high voltage-gated calcium channel activity|
|spindle midzone|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of voltage-gated calcium channel activity|
|calcium channel regulator activity|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of cation channel activity|
|cytoplasmic side of plasma membrane|
|metaphase plate congression|
|negative regulation of calcium ion transport|
|negative regulation of ion transmembrane transporter activity|
|establishment of chromosome localization|
|chromosome localization|
|GDP binding|
|mitotic spindle|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transport|
|negative regulation of transmembrane transport|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|midbody|
|regulation of cation channel activity|
|calmodulin binding|
|magnesium ion binding|
|nuclear chromosome segregation|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|chromosome segregation|
|regulation of transporter activity|
|GTPase activity|
|regulation of cation transmembrane transport|
|establishment of organelle localization|
|regulation of metal ion transport|
|GTP binding|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of transmembrane transport|
|organelle localization|
|mitotic cell cycle|
|regulation of ion transport|
|cell cycle process|
|chromosome organization|
|negative regulation of molecular function|
|cell cycle|
|establishment of localization in cell|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15829
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GEM Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>