======= GFER =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GFER
  * **<color #00a2e8>Official Name</color>**: growth factor, augmenter of liver regeneration
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2671|2671]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55789|P55789]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GFER&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFER|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600924|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Evr1 Alr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|flavin-linked sulfhydryl oxidase activity|
|protein disulfide oxidoreductase activity|
|flavin adenine dinucleotide binding|
|mitochondrial intermembrane space|
|growth factor activity|
|oxidation-reduction process|
|mitochondrion|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.9|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.92|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.99|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.09|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.1|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.539|
|[[:human genes:h:hccs|HCCS]]|0.499|
|[[:human genes:t:triap1|TRIAP1]]|0.487|
|[[:human genes:p:pmm2|PMM2]]|0.482|
|[[:human genes:g:gmppb|GMPPB]]|0.479|
|[[:human genes:g:gfpt1|GFPT1]]|0.477|
|[[:human genes:d:dpagt1|DPAGT1]]|0.454|
|[[:human genes:c:cycs|CYCS]]|0.453|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.453|
|[[:human genes:a:atxn10|ATXN10]]|0.452|
|[[:human genes:h:hspd1|HSPD1]]|0.45|
|[[:human genes:m:mrps14|MRPS14]]|0.446|
|[[:human genes:a:aars|AARS]]|0.439|
|[[:human genes:e:elac2|ELAC2]]|0.439|
|[[:human genes:t:thoc6|THOC6]]|0.435|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.431|
|[[:human genes:c:crls1|CRLS1]]|0.422|
|[[:human genes:c:cox16|COX16]]|0.416|
|[[:human genes:e:eny2|ENY2]]|0.415|
|[[:human genes:a:alg1|ALG1]]|0.412|
|[[:human genes:m:mrpl15|MRPL15]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.408|
|[[:human genes:t:tbca|TBCA]]|0.405|
|[[:human genes:a:atp5j|ATP5J]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 138/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|7/28|
|bone|6/26|
|breast|1/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|7/21|
|liver|7/20|
|lung|13/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|4/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 642
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GFER Expression in NALM6 Cells: 3.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>