======= GFM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GFM2
  * **<color #00a2e8>Official Name</color>**: GTP dependent ribosome recycling factor mitochondrial 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84340|84340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969S9|Q969S9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GFM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606544|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. {ECO:0000255|HAMAP-Rule:MF_03059, ECO:0000269|PubMed:19716793}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EFG IV|
|EFG C|
|GTP EFTU|
|GTP EFTU D2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome disassembly|
|ribonucleoprotein complex disassembly|
|translation elongation factor activity|
|organelle disassembly|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|GTPase activity|
|mitochondrial matrix|
|translation|
|GTP binding|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.16|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.07|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.99|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.93|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.79|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.71|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.78|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.81|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.86|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.98|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.99|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.03|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.07|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.1|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.1|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.13|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.14|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.25|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.27|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.29|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.32|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.34|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.35|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.55|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.62|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtpbp10|GTPBP10]]|0.655|
|[[:human genes:q:qrsl1|QRSL1]]|0.649|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.643|
|[[:human genes:r:rpusd4|RPUSD4]]|0.635|
|[[:human genes:m:mrps34|MRPS34]]|0.63|
|[[:human genes:d:dars2|DARS2]]|0.626|
|[[:human genes:m:mrpl21|MRPL21]]|0.622|
|[[:human genes:m:mrps16|MRPS16]]|0.621|
|[[:human genes:s:selrc1|SELRC1]]|0.62|
|[[:human genes:n:ndufb11|NDUFB11]]|0.613|
|[[:human genes:r:rpusd3|RPUSD3]]|0.613|
|[[:human genes:m:mrps26|MRPS26]]|0.608|
|[[:human genes:n:ndufa3|NDUFA3]]|0.608|
|[[:human genes:l:lars2|LARS2]]|0.607|
|[[:human genes:m:mrps5|MRPS5]]|0.604|
|[[:human genes:m:mrpl53|MRPL53]]|0.602|
|[[:human genes:g:gfm1|GFM1]]|0.6|
|[[:human genes:c:c12orf65|C12orf65]]|0.6|
|[[:human genes:m:mrps6|MRPS6]]|0.598|
|[[:human genes:s:sco2|SCO2]]|0.598|
|[[:human genes:b:bcs1l|BCS1L]]|0.597|
|[[:human genes:m:mrpl23|MRPL23]]|0.595|
|[[:human genes:t:tars2|TARS2]]|0.595|
|[[:human genes:y:yars2|YARS2]]|0.593|
|[[:human genes:n:nars2|NARS2]]|0.593|
|[[:human genes:p:pars2|PARS2]]|0.592|
|[[:human genes:m:mrpl15|MRPL15]]|0.591|
|[[:human genes:d:dap3|DAP3]]|0.588|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.584|
|[[:human genes:p:pet112|PET112]]|0.583|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.582|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.578|
|[[:human genes:m:mrpl47|MRPL47]]|0.576|
|[[:human genes:e:ears2|EARS2]]|0.576|
|[[:human genes:m:mtg1|MTG1]]|0.574|
|[[:human genes:c:c17orf89|C17orf89]]|0.571|
|[[:human genes:r:rbfa|RBFA]]|0.571|
|[[:human genes:a:aars2|AARS2]]|0.569|
|[[:human genes:m:mrps14|MRPS14]]|0.569|
|[[:human genes:m:mettl17|METTL17]]|0.567|
|[[:human genes:w:wbscr16|WBSCR16]]|0.566|
|[[:human genes:f:ftsj2|FTSJ2]]|0.565|
|[[:human genes:c:cox16|COX16]]|0.564|
|[[:human genes:c:coa6|COA6]]|0.562|
|[[:human genes:m:mrps21|MRPS21]]|0.561|
|[[:human genes:n:ndufc2|NDUFC2]]|0.561|
|[[:human genes:c:chchd1|CHCHD1]]|0.56|
|[[:human genes:n:ndufa2|NDUFA2]]|0.559|
|[[:human genes:v:vars2|VARS2]]|0.557|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.557|
|[[:human genes:m:mtpap|MTPAP]]|0.556|
|[[:human genes:m:mtg2|MTG2]]|0.551|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.549|
|[[:human genes:n:ndufb5|NDUFB5]]|0.544|
|[[:human genes:m:mrpl45|MRPL45]]|0.542|
|[[:human genes:r:rars2|RARS2]]|0.542|
|[[:human genes:n:ndufb6|NDUFB6]]|0.542|
|[[:human genes:m:mrp63|MRP63]]|0.54|
|[[:human genes:h:hars2|HARS2]]|0.539|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.535|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.535|
|[[:human genes:s:slc25a26|SLC25A26]]|0.531|
|[[:human genes:w:wars2|WARS2]]|0.53|
|[[:human genes:m:mcat|MCAT]]|0.53|
|[[:human genes:n:ndufa1|NDUFA1]]|0.529|
|[[:human genes:c:coa3|COA3]]|0.528|
|[[:human genes:f:fastkd2|FASTKD2]]|0.526|
|[[:human genes:f:fastkd5|FASTKD5]]|0.526|
|[[:human genes:n:ndufs2|NDUFS2]]|0.526|
|[[:human genes:p:pnpt1|PNPT1]]|0.526|
|[[:human genes:m:mrpl20|MRPL20]]|0.524|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.522|
|[[:human genes:m:mrps2|MRPS2]]|0.519|
|[[:human genes:c:cox11|COX11]]|0.519|
|[[:human genes:m:mrpl55|MRPL55]]|0.518|
|[[:human genes:f:foxred1|FOXRED1]]|0.517|
|[[:human genes:e:ecsit|ECSIT]]|0.517|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.517|
|[[:human genes:p:pitrm1|PITRM1]]|0.517|
|[[:human genes:c:coq2|COQ2]]|0.517|
|[[:human genes:m:malsu1|MALSU1]]|0.517|
|[[:human genes:c:cox15|COX15]]|0.515|
|[[:human genes:g:gatc|GATC]]|0.513|
|[[:human genes:m:mars2|MARS2]]|0.512|
|[[:human genes:n:ndufb9|NDUFB9]]|0.511|
|[[:human genes:m:mrps22|MRPS22]]|0.51|
|[[:human genes:m:mrps25|MRPS25]]|0.51|
|[[:human genes:p:polg2|POLG2]]|0.51|
|[[:human genes:m:mrpl42|MRPL42]]|0.509|
|[[:human genes:p:pet117|PET117]]|0.507|
|[[:human genes:a:atp5sl|ATP5SL]]|0.506|
|[[:human genes:m:mrpl12|MRPL12]]|0.506|
|[[:human genes:m:mterfd1|MTERFD1]]|0.506|
|[[:human genes:c:cars2|CARS2]]|0.506|
|[[:human genes:t:tefm|TEFM]]|0.506|
|[[:human genes:t:tmem242|TMEM242]]|0.505|
|[[:human genes:m:mto1|MTO1]]|0.505|
|[[:human genes:m:mrps9|MRPS9]]|0.502|
|[[:human genes:m:mrps24|MRPS24]]|0.501|
|[[:human genes:i:iba57|IBA57]]|0.5|
|[[:human genes:m:mrps23|MRPS23]]|0.499|
|[[:human genes:m:mrps12|MRPS12]]|0.498|
|[[:human genes:s:sars2|SARS2]]|0.498|
|[[:human genes:m:mrpl44|MRPL44]]|0.497|
|[[:human genes:m:mrpl11|MRPL11]]|0.496|
|[[:human genes:t:timm8b|TIMM8B]]|0.496|
|[[:human genes:n:ndufs7|NDUFS7]]|0.496|
|[[:human genes:t:tufm|TUFM]]|0.495|
|[[:human genes:t:tomm6|TOMM6]]|0.493|
|[[:human genes:m:mrpl22|MRPL22]]|0.491|
|[[:human genes:c:coq7|COQ7]]|0.491|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.491|
|[[:human genes:m:mrps18a|MRPS18A]]|0.491|
|[[:human genes:a:atp5d|ATP5D]]|0.489|
|[[:human genes:t:trub2|TRUB2]]|0.488|
|[[:human genes:n:ndufa11|NDUFA11]]|0.486|
|[[:human genes:a:aifm1|AIFM1]]|0.486|
|[[:human genes:m:mrpl4|MRPL4]]|0.485|
|[[:human genes:m:mipep|MIPEP]]|0.484|
|[[:human genes:t:tmem261|TMEM261]]|0.484|
|[[:human genes:g:grsf1|GRSF1]]|0.483|
|[[:human genes:m:mrps33|MRPS33]]|0.481|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.48|
|[[:human genes:s:ssbp1|SSBP1]]|0.479|
|[[:human genes:f:fars2|FARS2]]|0.478|
|[[:human genes:p:polrmt|POLRMT]]|0.478|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.478|
|[[:human genes:p:pdss1|PDSS1]]|0.477|
|[[:human genes:s:slc25a3|SLC25A3]]|0.475|
|[[:human genes:c:c10orf2|C10orf2]]|0.473|
|[[:human genes:n:nubpl|NUBPL]]|0.472|
|[[:human genes:d:dhx30|DHX30]]|0.471|
|[[:human genes:m:mtif3|MTIF3]]|0.471|
|[[:human genes:p:polg|POLG]]|0.47|
|[[:human genes:d:dnlz|DNLZ]]|0.47|
|[[:human genes:s:sco1|SCO1]]|0.468|
|[[:human genes:m:mterfd2|MTERFD2]]|0.467|
|[[:human genes:e:eral1|ERAL1]]|0.465|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.464|
|[[:human genes:c:cox17|COX17]]|0.462|
|[[:human genes:i:ict1|ICT1]]|0.462|
|[[:human genes:m:mrps11|MRPS11]]|0.462|
|[[:human genes:l:lsm10|LSM10]]|0.461|
|[[:human genes:a:acad9|ACAD9]]|0.46|
|[[:human genes:n:ndufs5|NDUFS5]]|0.46|
|[[:human genes:m:mrps10|MRPS10]]|0.46|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.457|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.457|
|[[:human genes:p:pgm3|PGM3]]|0.455|
|[[:human genes:t:trmt10a|TRMT10A]]|0.454|
|[[:human genes:m:mrpl2|MRPL2]]|0.453|
|[[:human genes:m:mrpl49|MRPL49]]|0.452|
|[[:human genes:m:mrpl18|MRPL18]]|0.451|
|[[:human genes:n:ndufa8|NDUFA8]]|0.451|
|[[:human genes:d:dhrsx|DHRSX]]|0.449|
|[[:human genes:m:mtfmt|MTFMT]]|0.449|
|[[:human genes:m:mrpl3|MRPL3]]|0.447|
|[[:human genes:n:ndufb7|NDUFB7]]|0.447|
|[[:human genes:m:mrps7|MRPS7]]|0.447|
|[[:human genes:m:mtif2|MTIF2]]|0.447|
|[[:human genes:n:ndufa10|NDUFA10]]|0.446|
|[[:human genes:c:cox7b|COX7B]]|0.445|
|[[:human genes:t:triap1|TRIAP1]]|0.445|
|[[:human genes:m:mrpl39|MRPL39]]|0.445|
|[[:human genes:t:tomm20|TOMM20]]|0.443|
|[[:human genes:c:cox19|COX19]]|0.443|
|[[:human genes:n:ndufb3|NDUFB3]]|0.442|
|[[:human genes:a:atp5c1|ATP5C1]]|0.439|
|[[:human genes:c:coq5|COQ5]]|0.439|
|[[:human genes:u:uqcc2|UQCC2]]|0.436|
|[[:human genes:n:ndufv1|NDUFV1]]|0.436|
|[[:human genes:t:tomm40|TOMM40]]|0.435|
|[[:human genes:o:opa1|OPA1]]|0.433|
|[[:human genes:m:mtrf1|MTRF1]]|0.433|
|[[:human genes:m:mrpl17|MRPL17]]|0.432|
|[[:human genes:g:glrx5|GLRX5]]|0.432|
|[[:human genes:d:ddx28|DDX28]]|0.432|
|[[:human genes:n:nfu1|NFU1]]|0.429|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.429|
|[[:human genes:a:ak3|AK3]]|0.428|
|[[:human genes:t:tmem126b|TMEM126B]]|0.428|
|[[:human genes:a:alg6|ALG6]]|0.423|
|[[:human genes:c:coq3|COQ3]]|0.422|
|[[:human genes:c:clpp|CLPP]]|0.421|
|[[:human genes:m:mrpl43|MRPL43]]|0.42|
|[[:human genes:f:fh|FH]]|0.42|
|[[:human genes:a:atp5h|ATP5H]]|0.419|
|[[:human genes:c:cox6c|COX6C]]|0.417|
|[[:human genes:t:tfb1m|TFB1M]]|0.417|
|[[:human genes:n:ndufb10|NDUFB10]]|0.416|
|[[:human genes:m:mrpl52|MRPL52]]|0.416|
|[[:human genes:t:trmt61a|TRMT61A]]|0.415|
|[[:human genes:c:coq6|COQ6]]|0.413|
|[[:human genes:u:uqcr10|UQCR10]]|0.413|
|[[:human genes:a:atp5b|ATP5B]]|0.411|
|[[:human genes:m:mrpl13|MRPL13]]|0.411|
|[[:human genes:e:elac2|ELAC2]]|0.409|
|[[:human genes:n:ndufs1|NDUFS1]]|0.408|
|[[:human genes:t:tpk1|TPK1]]|0.408|
|[[:human genes:m:mrpl34|MRPL34]]|0.408|
|[[:human genes:r:rpe|RPE]]|0.407|
|[[:human genes:n:ndufa5|NDUFA5]]|0.407|
|[[:human genes:p:ptcd1|PTCD1]]|0.407|
|[[:human genes:m:mrps17|MRPS17]]|0.406|
|[[:human genes:a:atp5a1|ATP5A1]]|0.405|
|[[:human genes:m:minos1|MINOS1]]|0.404|
|[[:human genes:m:mrpl36|MRPL36]]|0.403|
|[[:human genes:n:ndufb1|NDUFB1]]|0.402|
|[[:human genes:c:coa5|COA5]]|0.401|
|[[:human genes:n:ndufs8|NDUFS8]]|0.401|
|[[:human genes:r:rpia|RPIA]]|0.4|
|[[:human genes:h:hemk1|HEMK1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2830
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GFM2 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>