======= GFPT1 =======
== Gene Information ==
* **Official Symbol**: GFPT1
* **Official Name**: glutamine--fructose-6-phosphate transaminase 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2673|2673]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q06210|Q06210]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=GFPT1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFPT1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/138292|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008].
* **UniProt Summary**: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
|GATase 2|
|SIS|
|carbohydrate derivative binding|
|glutamine-fructose-6-phosphate transaminase (isomerizing) activity|
|fructose 6-phosphate metabolic process|
|UDP-N-acetylglucosamine biosynthetic process|
|amino sugar biosynthetic process|
|UDP-N-acetylglucosamine metabolic process|
|glutamine metabolic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|IRE1-mediated unfolded protein response|
|circadian regulation of gene expression|
|energy reserve metabolic process|
|glutamine family amino acid metabolic process|
|protein N-linked glycosylation|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|circadian rhythm|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to topologically incorrect protein|
|alpha-amino acid metabolic process|
|energy derivation by oxidation of organic compounds|
|protein glycosylation|
|macromolecule glycosylation|
|response to endoplasmic reticulum stress|
|glycosylation|
|rhythmic process|
|cellular amino acid metabolic process|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|generation of precursor metabolites and energy|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.28|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.23|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.18|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.03|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.99|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.99|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.97|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.92|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.9|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.82|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.81|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.8|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.8|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.8|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.75|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.74|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.72|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM on day4 R07 exp419]]|-1.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.72|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.9|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.9|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.92|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.99|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.07|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.12|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.17|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.18|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.35|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.38|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.43|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.45|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.56|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.62|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.92|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.1|
^Gene^Correlation^
|[[:human genes:u:uap1|UAP1]]|0.747|
|[[:human genes:d:dpagt1|DPAGT1]]|0.736|
|[[:human genes:t:thg1l|THG1L]]|0.711|
|[[:human genes:g:gmppb|GMPPB]]|0.703|
|[[:human genes:r:rtcb|RTCB]]|0.69|
|[[:human genes:p:pmm2|PMM2]]|0.69|
|[[:human genes:r:rptor|RPTOR]]|0.66|
|[[:human genes:a:alg1|ALG1]]|0.656|
|[[:human genes:d:dohh|DOHH]]|0.649|
|[[:human genes:t:triap1|TRIAP1]]|0.648|
|[[:human genes:r:rnmt|RNMT]]|0.646|
|[[:human genes:h:hspd1|HSPD1]]|0.643|
|[[:human genes:g:gnb1l|GNB1L]]|0.629|
|[[:human genes:a:atp5j|ATP5J]]|0.625|
|[[:human genes:e:eny2|ENY2]]|0.623|
|[[:human genes:n:nae1|NAE1]]|0.619|
|[[:human genes:h:hars|HARS]]|0.617|
|[[:human genes:c:csnk2b|CSNK2B]]|0.616|
|[[:human genes:a:atxn10|ATXN10]]|0.612|
|[[:human genes:a:alg13|ALG13]]|0.609|
|[[:human genes:o:oraov1|ORAOV1]]|0.607|
|[[:human genes:a:alg5|ALG5]]|0.604|
|[[:human genes:m:mtor|MTOR]]|0.591|
|[[:human genes:p:plaa|PLAA]]|0.59|
|[[:human genes:u:ube2k|UBE2K]]|0.581|
|[[:human genes:t:tsen54|TSEN54]]|0.581|
|[[:human genes:h:hccs|HCCS]]|0.577|
|[[:human genes:u:uhrf1|UHRF1]]|0.576|
|[[:human genes:e:eif4e|EIF4E]]|0.574|
|[[:human genes:r:rpp21|RPP21]]|0.574|
|[[:human genes:a:alg2|ALG2]]|0.573|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.572|
|[[:human genes:m:med16|MED16]]|0.571|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.569|
|[[:human genes:s:srp14|SRP14]]|0.567|
|[[:human genes:c:ccdc101|CCDC101]]|0.563|
|[[:human genes:t:tsen34|TSEN34]]|0.56|
|[[:human genes:b:bap1|BAP1]]|0.557|
|[[:human genes:c:casp9|CASP9]]|0.557|
|[[:human genes:p:pelo|PELO]]|0.557|
|[[:human genes:d:dad1|DAD1]]|0.551|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.551|
|[[:human genes:t:tti2|TTI2]]|0.549|
|[[:human genes:c:cbfb|CBFB]]|0.548|
|[[:human genes:p:ppa2|PPA2]]|0.548|
|[[:human genes:e:exoc4|EXOC4]]|0.544|
|[[:human genes:a:adsl|ADSL]]|0.542|
|[[:human genes:c:cycs|CYCS]]|0.539|
|[[:human genes:d:dolk|DOLK]]|0.538|
|[[:human genes:u:ube2g2|UBE2G2]]|0.537|
|[[:human genes:a:apaf1|APAF1]]|0.535|
|[[:human genes:a:aars|AARS]]|0.531|
|[[:human genes:m:mars|MARS]]|0.531|
|[[:human genes:t:tbca|TBCA]]|0.531|
|[[:human genes:a:atp5b|ATP5B]]|0.53|
|[[:human genes:t:tamm41|TAMM41]]|0.528|
|[[:human genes:t:tmem41b|TMEM41B]]|0.527|
|[[:human genes:d:dhdds|DHDDS]]|0.526|
|[[:human genes:v:vezt|VEZT]]|0.525|
|[[:human genes:d:dhps|DHPS]]|0.524|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.523|
|[[:human genes:u:ubqln1|UBQLN1]]|0.523|
|[[:human genes:p:ppcs|PPCS]]|0.522|
|[[:human genes:b:bak1|BAK1]]|0.522|
|[[:human genes:a:atp5o|ATP5O]]|0.519|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.519|
|[[:human genes:v:vmp1|VMP1]]|0.518|
|[[:human genes:t:trnt1|TRNT1]]|0.516|
|[[:human genes:m:meaf6|MEAF6]]|0.516|
|[[:human genes:n:nars|NARS]]|0.515|
|[[:human genes:p:pam16|PAM16]]|0.513|
|[[:human genes:f:faf2|FAF2]]|0.513|
|[[:human genes:o:osgep|OSGEP]]|0.513|
|[[:human genes:n:nxt1|NXT1]]|0.511|
|[[:human genes:t:timm13|TIMM13]]|0.511|
|[[:human genes:m:mbtps2|MBTPS2]]|0.51|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.509|
|[[:human genes:k:kdsr|KDSR]]|0.507|
|[[:human genes:p:polr3h|POLR3H]]|0.507|
|[[:human genes:n:nsmce1|NSMCE1]]|0.507|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.505|
|[[:human genes:t:tti1|TTI1]]|0.505|
|[[:human genes:a:alg14|ALG14]]|0.504|
|[[:human genes:t:telo2|TELO2]]|0.503|
|[[:human genes:t:tbp|TBP]]|0.503|
|[[:human genes:r:rpn1|RPN1]]|0.502|
|[[:human genes:s:slc25a26|SLC25A26]]|0.502|
|[[:human genes:w:wdr24|WDR24]]|0.5|
|[[:human genes:d:dpf2|DPF2]]|0.499|
|[[:human genes:s:srp72|SRP72]]|0.499|
|[[:human genes:n:nsd1|NSD1]]|0.498|
|[[:human genes:t:taz|TAZ]]|0.498|
|[[:human genes:r:rpe|RPE]]|0.497|
|[[:human genes:w:wdr59|WDR59]]|0.496|
|[[:human genes:m:mllt1|MLLT1]]|0.494|
|[[:human genes:u:utp23|UTP23]]|0.492|
|[[:human genes:a:alg6|ALG6]]|0.492|
|[[:human genes:t:thoc6|THOC6]]|0.491|
|[[:human genes:u:uba3|UBA3]]|0.488|
|[[:human genes:a:atp2a2|ATP2A2]]|0.488|
|[[:human genes:t:trmt5|TRMT5]]|0.488|
|[[:human genes:d:dr1|DR1]]|0.486|
|[[:human genes:r:romo1|ROMO1]]|0.485|
|[[:human genes:g:gtf3a|GTF3A]]|0.485|
|[[:human genes:t:trmt10a|TRMT10A]]|0.484|
|[[:human genes:y:yars|YARS]]|0.482|
|[[:human genes:v:vhl|VHL]]|0.482|
|[[:human genes:c:cars|CARS]]|0.481|
|[[:human genes:c:cept1|CEPT1]]|0.481|
|[[:human genes:m:med4|MED4]]|0.481|
|[[:human genes:e:elac2|ELAC2]]|0.48|
|[[:human genes:g:gfer|GFER]]|0.477|
|[[:human genes:u:uso1|USO1]]|0.476|
|[[:human genes:g:gemin5|GEMIN5]]|0.476|
|[[:human genes:p:ppp4c|PPP4C]]|0.474|
|[[:human genes:d:ddx55|DDX55]]|0.473|
|[[:human genes:c:cct7|CCT7]]|0.473|
|[[:human genes:s:ssb|SSB]]|0.473|
|[[:human genes:d:ddx20|DDX20]]|0.472|
|[[:human genes:z:znf259|ZNF259]]|0.472|
|[[:human genes:c:crls1|CRLS1]]|0.472|
|[[:human genes:u:uxt|UXT]]|0.472|
|[[:human genes:l:lsm11|LSM11]]|0.471|
|[[:human genes:s:serf2|SERF2]]|0.471|
|[[:human genes:a:atp5a1|ATP5A1]]|0.468|
|[[:human genes:e:eif3f|EIF3F]]|0.467|
|[[:human genes:d:ddx1|DDX1]]|0.466|
|[[:human genes:t:timm22|TIMM22]]|0.466|
|[[:human genes:e:eno1|ENO1]]|0.465|
|[[:human genes:s:slc25a19|SLC25A19]]|0.463|
|[[:human genes:o:otud5|OTUD5]]|0.462|
|[[:human genes:z:zrsr2|ZRSR2]]|0.461|
|[[:human genes:t:tgs1|TGS1]]|0.46|
|[[:human genes:e:exoc3|EXOC3]]|0.459|
|[[:human genes:s:sec16a|SEC16A]]|0.459|
|[[:human genes:h:haus8|HAUS8]]|0.459|
|[[:human genes:d:dhrsx|DHRSX]]|0.456|
|[[:human genes:s:slc35b1|SLC35B1]]|0.456|
|[[:human genes:s:srprb|SRPRB]]|0.456|
|[[:human genes:a:atp5i|ATP5I]]|0.456|
|[[:human genes:a:atp5d|ATP5D]]|0.456|
|[[:human genes:n:nup50|NUP50]]|0.455|
|[[:human genes:s:srp68|SRP68]]|0.455|
|[[:human genes:r:rft1|RFT1]]|0.455|
|[[:human genes:t:tbcb|TBCB]]|0.455|
|[[:human genes:s:sec62|SEC62]]|0.454|
|[[:human genes:s:spcs3|SPCS3]]|0.454|
|[[:human genes:l:lsm10|LSM10]]|0.453|
|[[:human genes:l:lsmd1|LSMD1]]|0.452|
|[[:human genes:t:thoc3|THOC3]]|0.452|
|[[:human genes:w:wdr1|WDR1]]|0.451|
|[[:human genes:e:eprs|EPRS]]|0.45|
|[[:human genes:t:ttc4|TTC4]]|0.45|
|[[:human genes:t:tmed10|TMED10]]|0.45|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.449|
|[[:human genes:r:rad1|RAD1]]|0.448|
|[[:human genes:m:mfn1|MFN1]]|0.447|
|[[:human genes:z:znf608|ZNF608]]|0.447|
|[[:human genes:v:vdac2|VDAC2]]|0.446|
|[[:human genes:d:ddost|DDOST]]|0.446|
|[[:human genes:m:march5|MARCH5]]|0.443|
|[[:human genes:o:oip5|OIP5]]|0.442|
|[[:human genes:g:gemin8|GEMIN8]]|0.441|
|[[:human genes:n:nupl2|NUPL2]]|0.44|
|[[:human genes:c:chchd4|CHCHD4]]|0.44|
|[[:human genes:v:vrk1|VRK1]]|0.439|
|[[:human genes:r:rabggtb|RABGGTB]]|0.439|
|[[:human genes:d:diablo|DIABLO]]|0.439|
|[[:human genes:f:fh|FH]]|0.439|
|[[:human genes:d:dnajc3|DNAJC3]]|0.438|
|[[:human genes:t:trim28|TRIM28]]|0.437|
|[[:human genes:m:med23|MED23]]|0.437|
|[[:human genes:e:elp3|ELP3]]|0.437|
|[[:human genes:c:crcp|CRCP]]|0.436|
|[[:human genes:p:pggt1b|PGGT1B]]|0.436|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.436|
|[[:human genes:p:pisd|PISD]]|0.435|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.435|
|[[:human genes:s:sec61g|SEC61G]]|0.435|
|[[:human genes:s:spcs2|SPCS2]]|0.435|
|[[:human genes:g:gabpa|GABPA]]|0.435|
|[[:human genes:c:chordc1|CHORDC1]]|0.434|
|[[:human genes:t:tufm|TUFM]]|0.433|
|[[:human genes:r:rpia|RPIA]]|0.431|
|[[:human genes:a:atp5h|ATP5H]]|0.431|
|[[:human genes:b:btaf1|BTAF1]]|0.431|
|[[:human genes:u:urm1|URM1]]|0.431|
|[[:human genes:m:med25|MED25]]|0.431|
|[[:human genes:q:qars|QARS]]|0.429|
|[[:human genes:t:ten1|TEN1]]|0.428|
|[[:human genes:s:seh1l|SEH1L]]|0.428|
|[[:human genes:p:polr3b|POLR3B]]|0.427|
|[[:human genes:f:fbxo11|FBXO11]]|0.427|
|[[:human genes:a:atic|ATIC]]|0.427|
|[[:human genes:s:srd5a3|SRD5A3]]|0.427|
|[[:human genes:z:zbtb11|ZBTB11]]|0.426|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.424|
|[[:human genes:r:rbm14|RBM14]]|0.423|
|[[:human genes:u:uba5|UBA5]]|0.423|
|[[:human genes:c:cep57|CEP57]]|0.422|
|[[:human genes:b:bcs1l|BCS1L]]|0.421|
|[[:human genes:f:fnta|FNTA]]|0.42|
|[[:human genes:o:opa1|OPA1]]|0.42|
|[[:human genes:p:pdap1|PDAP1]]|0.419|
|[[:human genes:t:tprkb|TPRKB]]|0.419|
|[[:human genes:m:mrps14|MRPS14]]|0.418|
|[[:human genes:p:ppp6c|PPP6C]]|0.418|
|[[:human genes:s:sec63|SEC63]]|0.417|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.417|
|[[:human genes:p:pik3r4|PIK3R4]]|0.416|
|[[:human genes:t:txnl4b|TXNL4B]]|0.416|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.415|
|[[:human genes:d:dhx29|DHX29]]|0.413|
|[[:human genes:p:pgm3|PGM3]]|0.413|
|[[:human genes:c:c10orf2|C10orf2]]|0.413|
|[[:human genes:t:tsen2|TSEN2]]|0.413|
|[[:human genes:c:cmtr1|CMTR1]]|0.411|
|[[:human genes:m:mis18a|MIS18A]]|0.411|
|[[:human genes:c:cdipt|CDIPT]]|0.41|
|[[:human genes:w:wdr82|WDR82]]|0.41|
|[[:human genes:g:gemin7|GEMIN7]]|0.407|
|[[:human genes:s:sars2|SARS2]]|0.407|
|[[:human genes:u:ube2m|UBE2M]]|0.407|
|[[:human genes:p:pcbp2|PCBP2]]|0.406|
|[[:human genes:m:mbtps1|MBTPS1]]|0.406|
|[[:human genes:w:wdr92|WDR92]]|0.406|
|[[:human genes:m:mapk14|MAPK14]]|0.404|
|[[:human genes:x:xpo5|XPO5]]|0.404|
|[[:human genes:s:sdha|SDHA]]|0.404|
|[[:human genes:t:txnrd1|TXNRD1]]|0.403|
|[[:human genes:g:gpn2|GPN2]]|0.402|
|[[:human genes:t:tomm40|TOMM40]]|0.401|
|[[:human genes:y:yars2|YARS2]]|0.401|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.401|
Global Fraction of Cell Lines Where Essential: 33/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|4/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|4/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 1006
* **Expression level (log2 read counts)**: 6.46
{{:chemogenomics:nalm6 dist.png?nolink |}}