======= GFPT1 ======= == Gene Information == * **Official Symbol**: GFPT1 * **Official Name**: glutamine--fructose-6-phosphate transaminase 1 * **Aliases and Previous Symbols**: N/A * **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2673|2673]] * **UniProt**: [[https://www.uniprot.org/uniprot/Q06210|Q06210]] * **Interactions**: [[https://thebiogrid.org/search.php?search=GFPT1&organism=9606|BioGRID]] * **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFPT1|Open PubMed]] * **OMIM**: [[https://omim.org/entry/138292|Open OMIM]] == Function Summary == * **Entrez Summary**: This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]. * **UniProt Summary**: Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. |GATase 2| |SIS| |carbohydrate derivative binding| |glutamine-fructose-6-phosphate transaminase (isomerizing) activity| |fructose 6-phosphate metabolic process| |UDP-N-acetylglucosamine biosynthetic process| |amino sugar biosynthetic process| |UDP-N-acetylglucosamine metabolic process| |glutamine metabolic process| |nucleotide-sugar biosynthetic process| |nucleotide-sugar metabolic process| |amino sugar metabolic process| |IRE1-mediated unfolded protein response| |circadian regulation of gene expression| |energy reserve metabolic process| |glutamine family amino acid metabolic process| |protein N-linked glycosylation| |endoplasmic reticulum unfolded protein response| |cellular response to unfolded protein| |circadian rhythm| |cellular response to topologically incorrect protein| |response to unfolded protein| |response to topologically incorrect protein| |alpha-amino acid metabolic process| |energy derivation by oxidation of organic compounds| |protein glycosylation| |macromolecule glycosylation| |response to endoplasmic reticulum stress| |glycosylation| |rhythmic process| |cellular amino acid metabolic process| |glycoprotein biosynthetic process| |glycoprotein metabolic process| |generation of precursor metabolites and energy| |nucleobase-containing small molecule metabolic process| |carbohydrate derivative biosynthetic process| |organophosphate metabolic process| |carboxylic acid metabolic process| |oxidation-reduction process| |oxoacid metabolic process| |organic acid metabolic process| |carbohydrate derivative metabolic process| |nucleobase-containing compound biosynthetic process| |heterocycle biosynthetic process| |aromatic compound biosynthetic process| |organic cyclic compound biosynthetic process| |organonitrogen compound biosynthetic process| |cellular nitrogen compound biosynthetic process| |cellular response to stress| |cellular macromolecule biosynthetic process| |small molecule metabolic process| |macromolecule biosynthetic process| \\ === CRISPR Data === ^Screen^Score^ |[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.28| |[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.23| |[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.18| |[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.03| |[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2| |[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.99| |[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.99| |[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.97| |[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.92| |[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.9| |[[:results:exp483|FTY720 3μM R08 exp483]]|-1.82| |[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.81| |[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.8| |[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.8| |[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.8| |[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.75| |[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.74| |[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.72| |[[:results:exp419|Tunicamycin 0.04 to 0.075μM on day4 R07 exp419]]|-1.72| |[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.72| |[[:results:exp17|DABN 20μM R00 exp17]]|1.89| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.9| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.9| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.92| |[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.99| |[[:results:exp93|DABN racemic mixture R03 exp93]]|2| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.07| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09| |[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.12| |[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.17| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.18| |[[:results:exp532|TIC10 10μM R08 exp532]]|2.35| |[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.38| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.43| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.45| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.56| |[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.62| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.92| |[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.1| ^Gene^Correlation^ |[[:human genes:u:uap1|UAP1]]|0.747| |[[:human genes:d:dpagt1|DPAGT1]]|0.736| |[[:human genes:t:thg1l|THG1L]]|0.711| |[[:human genes:g:gmppb|GMPPB]]|0.703| |[[:human genes:r:rtcb|RTCB]]|0.69| |[[:human genes:p:pmm2|PMM2]]|0.69| |[[:human genes:r:rptor|RPTOR]]|0.66| |[[:human genes:a:alg1|ALG1]]|0.656| |[[:human genes:d:dohh|DOHH]]|0.649| |[[:human genes:t:triap1|TRIAP1]]|0.648| |[[:human genes:r:rnmt|RNMT]]|0.646| |[[:human genes:h:hspd1|HSPD1]]|0.643| |[[:human genes:g:gnb1l|GNB1L]]|0.629| |[[:human genes:a:atp5j|ATP5J]]|0.625| |[[:human genes:e:eny2|ENY2]]|0.623| |[[:human genes:n:nae1|NAE1]]|0.619| |[[:human genes:h:hars|HARS]]|0.617| |[[:human genes:c:csnk2b|CSNK2B]]|0.616| |[[:human genes:a:atxn10|ATXN10]]|0.612| |[[:human genes:a:alg13|ALG13]]|0.609| |[[:human genes:o:oraov1|ORAOV1]]|0.607| |[[:human genes:a:alg5|ALG5]]|0.604| |[[:human genes:m:mtor|MTOR]]|0.591| |[[:human genes:p:plaa|PLAA]]|0.59| |[[:human genes:u:ube2k|UBE2K]]|0.581| |[[:human genes:t:tsen54|TSEN54]]|0.581| |[[:human genes:h:hccs|HCCS]]|0.577| |[[:human genes:u:uhrf1|UHRF1]]|0.576| |[[:human genes:e:eif4e|EIF4E]]|0.574| |[[:human genes:r:rpp21|RPP21]]|0.574| |[[:human genes:a:alg2|ALG2]]|0.573| |[[:human genes:c:ctdnep1|CTDNEP1]]|0.572| |[[:human genes:m:med16|MED16]]|0.571| |[[:human genes:g:gtf3c3|GTF3C3]]|0.569| |[[:human genes:s:srp14|SRP14]]|0.567| |[[:human genes:c:ccdc101|CCDC101]]|0.563| |[[:human genes:t:tsen34|TSEN34]]|0.56| |[[:human genes:b:bap1|BAP1]]|0.557| |[[:human genes:c:casp9|CASP9]]|0.557| |[[:human genes:p:pelo|PELO]]|0.557| |[[:human genes:d:dad1|DAD1]]|0.551| |[[:human genes:g:gtf3c4|GTF3C4]]|0.551| |[[:human genes:t:tti2|TTI2]]|0.549| |[[:human genes:c:cbfb|CBFB]]|0.548| |[[:human genes:p:ppa2|PPA2]]|0.548| |[[:human genes:e:exoc4|EXOC4]]|0.544| |[[:human genes:a:adsl|ADSL]]|0.542| |[[:human genes:c:cycs|CYCS]]|0.539| |[[:human genes:d:dolk|DOLK]]|0.538| |[[:human genes:u:ube2g2|UBE2G2]]|0.537| |[[:human genes:a:apaf1|APAF1]]|0.535| |[[:human genes:a:aars|AARS]]|0.531| |[[:human genes:m:mars|MARS]]|0.531| |[[:human genes:t:tbca|TBCA]]|0.531| |[[:human genes:a:atp5b|ATP5B]]|0.53| |[[:human genes:t:tamm41|TAMM41]]|0.528| |[[:human genes:t:tmem41b|TMEM41B]]|0.527| |[[:human genes:d:dhdds|DHDDS]]|0.526| |[[:human genes:v:vezt|VEZT]]|0.525| |[[:human genes:d:dhps|DHPS]]|0.524| |[[:human genes:g:gtf3c6|GTF3C6]]|0.523| |[[:human genes:u:ubqln1|UBQLN1]]|0.523| |[[:human genes:p:ppcs|PPCS]]|0.522| |[[:human genes:b:bak1|BAK1]]|0.522| |[[:human genes:a:atp5o|ATP5O]]|0.519| |[[:human genes:g:gtf3c2|GTF3C2]]|0.519| |[[:human genes:v:vmp1|VMP1]]|0.518| |[[:human genes:t:trnt1|TRNT1]]|0.516| |[[:human genes:m:meaf6|MEAF6]]|0.516| |[[:human genes:n:nars|NARS]]|0.515| |[[:human genes:p:pam16|PAM16]]|0.513| |[[:human genes:f:faf2|FAF2]]|0.513| |[[:human genes:o:osgep|OSGEP]]|0.513| |[[:human genes:n:nxt1|NXT1]]|0.511| |[[:human genes:t:timm13|TIMM13]]|0.511| |[[:human genes:m:mbtps2|MBTPS2]]|0.51| |[[:human genes:p:ppp2r3c|PPP2R3C]]|0.509| |[[:human genes:k:kdsr|KDSR]]|0.507| |[[:human genes:p:polr3h|POLR3H]]|0.507| |[[:human genes:n:nsmce1|NSMCE1]]|0.507| |[[:human genes:l:lamtor5|LAMTOR5]]|0.505| |[[:human genes:t:tti1|TTI1]]|0.505| |[[:human genes:a:alg14|ALG14]]|0.504| |[[:human genes:t:telo2|TELO2]]|0.503| |[[:human genes:t:tbp|TBP]]|0.503| |[[:human genes:r:rpn1|RPN1]]|0.502| |[[:human genes:s:slc25a26|SLC25A26]]|0.502| |[[:human genes:w:wdr24|WDR24]]|0.5| |[[:human genes:d:dpf2|DPF2]]|0.499| |[[:human genes:s:srp72|SRP72]]|0.499| |[[:human genes:n:nsd1|NSD1]]|0.498| |[[:human genes:t:taz|TAZ]]|0.498| |[[:human genes:r:rpe|RPE]]|0.497| |[[:human genes:w:wdr59|WDR59]]|0.496| |[[:human genes:m:mllt1|MLLT1]]|0.494| |[[:human genes:u:utp23|UTP23]]|0.492| |[[:human genes:a:alg6|ALG6]]|0.492| |[[:human genes:t:thoc6|THOC6]]|0.491| |[[:human genes:u:uba3|UBA3]]|0.488| |[[:human genes:a:atp2a2|ATP2A2]]|0.488| |[[:human genes:t:trmt5|TRMT5]]|0.488| |[[:human genes:d:dr1|DR1]]|0.486| |[[:human genes:r:romo1|ROMO1]]|0.485| |[[:human genes:g:gtf3a|GTF3A]]|0.485| |[[:human genes:t:trmt10a|TRMT10A]]|0.484| |[[:human genes:y:yars|YARS]]|0.482| |[[:human genes:v:vhl|VHL]]|0.482| |[[:human genes:c:cars|CARS]]|0.481| |[[:human genes:c:cept1|CEPT1]]|0.481| |[[:human genes:m:med4|MED4]]|0.481| |[[:human genes:e:elac2|ELAC2]]|0.48| |[[:human genes:g:gfer|GFER]]|0.477| |[[:human genes:u:uso1|USO1]]|0.476| |[[:human genes:g:gemin5|GEMIN5]]|0.476| |[[:human genes:p:ppp4c|PPP4C]]|0.474| |[[:human genes:d:ddx55|DDX55]]|0.473| |[[:human genes:c:cct7|CCT7]]|0.473| |[[:human genes:s:ssb|SSB]]|0.473| |[[:human genes:d:ddx20|DDX20]]|0.472| |[[:human genes:z:znf259|ZNF259]]|0.472| |[[:human genes:c:crls1|CRLS1]]|0.472| |[[:human genes:u:uxt|UXT]]|0.472| |[[:human genes:l:lsm11|LSM11]]|0.471| |[[:human genes:s:serf2|SERF2]]|0.471| |[[:human genes:a:atp5a1|ATP5A1]]|0.468| |[[:human genes:e:eif3f|EIF3F]]|0.467| |[[:human genes:d:ddx1|DDX1]]|0.466| |[[:human genes:t:timm22|TIMM22]]|0.466| |[[:human genes:e:eno1|ENO1]]|0.465| |[[:human genes:s:slc25a19|SLC25A19]]|0.463| |[[:human genes:o:otud5|OTUD5]]|0.462| |[[:human genes:z:zrsr2|ZRSR2]]|0.461| |[[:human genes:t:tgs1|TGS1]]|0.46| |[[:human genes:e:exoc3|EXOC3]]|0.459| |[[:human genes:s:sec16a|SEC16A]]|0.459| |[[:human genes:h:haus8|HAUS8]]|0.459| |[[:human genes:d:dhrsx|DHRSX]]|0.456| |[[:human genes:s:slc35b1|SLC35B1]]|0.456| |[[:human genes:s:srprb|SRPRB]]|0.456| |[[:human genes:a:atp5i|ATP5I]]|0.456| |[[:human genes:a:atp5d|ATP5D]]|0.456| |[[:human genes:n:nup50|NUP50]]|0.455| |[[:human genes:s:srp68|SRP68]]|0.455| |[[:human genes:r:rft1|RFT1]]|0.455| |[[:human genes:t:tbcb|TBCB]]|0.455| |[[:human genes:s:sec62|SEC62]]|0.454| |[[:human genes:s:spcs3|SPCS3]]|0.454| |[[:human genes:l:lsm10|LSM10]]|0.453| |[[:human genes:l:lsmd1|LSMD1]]|0.452| |[[:human genes:t:thoc3|THOC3]]|0.452| |[[:human genes:w:wdr1|WDR1]]|0.451| |[[:human genes:e:eprs|EPRS]]|0.45| |[[:human genes:t:ttc4|TTC4]]|0.45| |[[:human genes:t:tmed10|TMED10]]|0.45| |[[:human genes:s:supv3l1|SUPV3L1]]|0.449| |[[:human genes:r:rad1|RAD1]]|0.448| |[[:human genes:m:mfn1|MFN1]]|0.447| |[[:human genes:z:znf608|ZNF608]]|0.447| |[[:human genes:v:vdac2|VDAC2]]|0.446| |[[:human genes:d:ddost|DDOST]]|0.446| |[[:human genes:m:march5|MARCH5]]|0.443| |[[:human genes:o:oip5|OIP5]]|0.442| |[[:human genes:g:gemin8|GEMIN8]]|0.441| |[[:human genes:n:nupl2|NUPL2]]|0.44| |[[:human genes:c:chchd4|CHCHD4]]|0.44| |[[:human genes:v:vrk1|VRK1]]|0.439| |[[:human genes:r:rabggtb|RABGGTB]]|0.439| |[[:human genes:d:diablo|DIABLO]]|0.439| |[[:human genes:f:fh|FH]]|0.439| |[[:human genes:d:dnajc3|DNAJC3]]|0.438| |[[:human genes:t:trim28|TRIM28]]|0.437| |[[:human genes:m:med23|MED23]]|0.437| |[[:human genes:e:elp3|ELP3]]|0.437| |[[:human genes:c:crcp|CRCP]]|0.436| |[[:human genes:p:pggt1b|PGGT1B]]|0.436| |[[:human genes:k:kiaa0391|KIAA0391]]|0.436| |[[:human genes:p:pisd|PISD]]|0.435| |[[:human genes:l:lamtor4|LAMTOR4]]|0.435| |[[:human genes:s:sec61g|SEC61G]]|0.435| |[[:human genes:s:spcs2|SPCS2]]|0.435| |[[:human genes:g:gabpa|GABPA]]|0.435| |[[:human genes:c:chordc1|CHORDC1]]|0.434| |[[:human genes:t:tufm|TUFM]]|0.433| |[[:human genes:r:rpia|RPIA]]|0.431| |[[:human genes:a:atp5h|ATP5H]]|0.431| |[[:human genes:b:btaf1|BTAF1]]|0.431| |[[:human genes:u:urm1|URM1]]|0.431| |[[:human genes:m:med25|MED25]]|0.431| |[[:human genes:q:qars|QARS]]|0.429| |[[:human genes:t:ten1|TEN1]]|0.428| |[[:human genes:s:seh1l|SEH1L]]|0.428| |[[:human genes:p:polr3b|POLR3B]]|0.427| |[[:human genes:f:fbxo11|FBXO11]]|0.427| |[[:human genes:a:atic|ATIC]]|0.427| |[[:human genes:s:srd5a3|SRD5A3]]|0.427| |[[:human genes:z:zbtb11|ZBTB11]]|0.426| |[[:human genes:u:uqcrc2|UQCRC2]]|0.424| |[[:human genes:r:rbm14|RBM14]]|0.423| |[[:human genes:u:uba5|UBA5]]|0.423| |[[:human genes:c:cep57|CEP57]]|0.422| |[[:human genes:b:bcs1l|BCS1L]]|0.421| |[[:human genes:f:fnta|FNTA]]|0.42| |[[:human genes:o:opa1|OPA1]]|0.42| |[[:human genes:p:pdap1|PDAP1]]|0.419| |[[:human genes:t:tprkb|TPRKB]]|0.419| |[[:human genes:m:mrps14|MRPS14]]|0.418| |[[:human genes:p:ppp6c|PPP6C]]|0.418| |[[:human genes:s:sec63|SEC63]]|0.417| |[[:human genes:a:aasdhppt|AASDHPPT]]|0.417| |[[:human genes:p:pik3r4|PIK3R4]]|0.416| |[[:human genes:t:txnl4b|TXNL4B]]|0.416| |[[:human genes:g:gtf2a2|GTF2A2]]|0.415| |[[:human genes:d:dhx29|DHX29]]|0.413| |[[:human genes:p:pgm3|PGM3]]|0.413| |[[:human genes:c:c10orf2|C10orf2]]|0.413| |[[:human genes:t:tsen2|TSEN2]]|0.413| |[[:human genes:c:cmtr1|CMTR1]]|0.411| |[[:human genes:m:mis18a|MIS18A]]|0.411| |[[:human genes:c:cdipt|CDIPT]]|0.41| |[[:human genes:w:wdr82|WDR82]]|0.41| |[[:human genes:g:gemin7|GEMIN7]]|0.407| |[[:human genes:s:sars2|SARS2]]|0.407| |[[:human genes:u:ube2m|UBE2M]]|0.407| |[[:human genes:p:pcbp2|PCBP2]]|0.406| |[[:human genes:m:mbtps1|MBTPS1]]|0.406| |[[:human genes:w:wdr92|WDR92]]|0.406| |[[:human genes:m:mapk14|MAPK14]]|0.404| |[[:human genes:x:xpo5|XPO5]]|0.404| |[[:human genes:s:sdha|SDHA]]|0.404| |[[:human genes:t:txnrd1|TXNRD1]]|0.403| |[[:human genes:g:gpn2|GPN2]]|0.402| |[[:human genes:t:tomm40|TOMM40]]|0.401| |[[:human genes:y:yars2|YARS2]]|0.401| |[[:human genes:p:pyroxd1|PYROXD1]]|0.401| Global Fraction of Cell Lines Where Essential: 33/726 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|4/28| |blood|4/28| |bone|0/25| |breast|1/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|1/13| |fibroblast|0/1| |gastric|0/15| |kidney|4/21| |liver|0/20| |lung|0/75| |lymphocyte|0/14| |ovary|1/26| |pancreas|3/24| |peripheral nervous system|0/16| |plasma cell|0/15| |prostate|0/1| |skin|1/24| |soft tissue|0/7| |thyroid|0/2| |upper aerodigestive|1/22| |urinary tract|2/29| |uterus|0/5| == Essentiality in NALM6 == * **Essentiality Rank**: 1006 * **Expression level (log2 read counts)**: 6.46 {{:chemogenomics:nalm6 dist.png?nolink |}}