======= GFRA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GFRA2
  * **<color #00a2e8>Official Name</color>**: GDNF family receptor alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2675|2675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00451|O00451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GFRA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GFRA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601956|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glial cell-derived neurotrophic factor receptor activity|
|glial cell-derived neurotrophic factor receptor signaling pathway|
|negative regulation of protein autophosphorylation|
|regulation of protein autophosphorylation|
|extrinsic component of membrane|
|anchored component of membrane|
|receptor complex|
|axon guidance|
|neuron projection guidance|
|MAPK cascade|
|axonogenesis|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|negative regulation of protein phosphorylation|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of phosphorylation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|protein phosphorylation|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|locomotion|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.21|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2.19|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.79|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.72|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7817
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GFRA2 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>