======= GHR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GHR
  * **<color #00a2e8>Official Name</color>**: growth hormone receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2690|2690]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10912|P10912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GHR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GHR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). {ECO:0000250}. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GHBP|
|fn3|
|EpoR lig-bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth hormone receptor activity|
|growth hormone receptor complex|
|activation of Janus kinase activity|
|taurine metabolic process|
|alkanesulfonate metabolic process|
|insulin-like growth factor receptor signaling pathway|
|growth hormone receptor signaling pathway via JAK-STAT|
|proline-rich region binding|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|positive regulation of multicellular organism growth|
|growth factor binding|
|response to growth hormone|
|receptor signaling pathway via JAK-STAT|
|peptide hormone binding|
|receptor signaling pathway via STAT|
|cytokine binding|
|cytokine receptor activity|
|regulation of multicellular organism growth|
|cytoplasmic ribonucleoprotein granule|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|regulation of receptor signaling pathway via JAK-STAT|
|xenobiotic metabolic process|
|regulation of receptor signaling pathway via STAT|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|activation of MAPK activity|
|positive regulation of developmental growth|
|cellular response to xenobiotic stimulus|
|positive regulation of peptidyl-tyrosine phosphorylation|
|hormone metabolic process|
|receptor complex|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|positive regulation of MAP kinase activity|
|cellular response to peptide hormone stimulus|
|response to xenobiotic stimulus|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|sulfur compound metabolic process|
|response to peptide hormone|
|external side of plasma membrane|
|protein kinase binding|
|response to peptide|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of MAPK cascade|
|endocytosis|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|import into cell|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|response to hormone|
|protein phosphorylation|
|regulation of transferase activity|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14890
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GHR Expression in NALM6 Cells: 2.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>